Effects of Alpha-interferon on Gamma-interferon Production of Peripheral Blood Mononuclear Cells in Hepatitis B Virus Carriers

Overview

Journal J Clin Immunol

Publisher Springer

Specialty Allergy & Immunology

Date 1992 Sep 1

PMID 1430105

Citations 3

Authors

K Katayama

N Hayashi

T Takehara

T Towata

A Kasahara

H Fusamoto

T Kamada

Affiliations

Soon will be listed here.

Abstract

We studied gamma-interferon production of phytohemagglutinin-stimulated peripheral blood mononuclear cells in response to alpha-interferon in hepatitis B virus carriers and healthy individuals. The magnitude of gamma-interferon production was significantly higher in patients with anti-HBe antibody than in patients with HBe antigen and healthy individuals. Furthermore, alpha-interferon augmented the production of gamma-interferon of peripheral blood mononuclear cells from patients with active liver injury [serum alanine aminotransferase (ALT), greater than 40 U/L], but not that from patients with inactive liver injury (serum ALT, less than 40 U/L) or healthy individuals. These results suggested that alpha-interferon could enhance the cellular immune response against hepatitis B virus by augmenting the endogenous production of gamma-interferon in patients with active liver injury, implying that the responsiveness to alpha-interferon might be responsible for liver cell injury.

Citing Articles

Sonographic fatty liver and hepatitis B virus carrier status: synergistic effect on liver damage in Taiwanese adults.

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Interferon-alpha-2a. A review of its pharmacological properties and therapeutic use in the management of viral hepatitis.

Haria M, Benfield P Drugs. 1995; 50(5):873-96.

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Alpha-interferon enhances gamma-interferon production of peripheral blood mononuclear cells pre-activated with phytohemagglutinin.

Katayama K, Hayashi N, Takehara T, Suzuki K, Kasahara A, Fusamoto H Gastroenterol Jpn. 1993; 28(5):673-8.

PMID: 8224618 DOI: 10.1007/BF02806348.

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