Diagnosis of Pneumococcal Pneumonia by Detection of Antigen in Saliva

Overview

Journal Eur J Clin Microbiol

Specialty Microbiology

Date 1986 Dec 1

PMID 3803376

Citations 7

Authors

A Krook

H Fredlund

H Holmberg

Affiliations

Soon will be listed here.

Abstract

A sandwich enzyme-linked immunosorbent assay was used for the detection of pneumococcal C polysaccharide in saliva samples from patients with radiologically verified pneumonia. In 16 of 29 patients (55%) with pneumococcal pneumonia, as verified by conventional culture methods, the antigen was present in saliva specimens. The test was negative in 35 of 36 patients (97%) with non-pneumococcal pneumonia and in all saliva samples from a control group, consisting of 25 patients with no signs of respiratory disease. It is concluded that the detection of pneumococcal C polysaccharide in saliva offers a valuable complement to conventional diagnostic methods for pneumococcal pneumonia.

Citing Articles

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Oropharyngeal production of pneumococcal capsular antigen and the potential for contamination of expectorated sputum samples in pneumococcal pneumonia.

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Diagnosis of Streptococcus pneumoniae pneumonia by quantitative enzyme linked immunosorbent assay of C-polysaccharide antigen.

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Comparison of three methods for detection of pneumococcal antigen in sputum of patients with community-acquired pneumonia.

Ortqvist A, Jonsson I, Kalin M, Krook A Eur J Clin Microbiol Infect Dis. 1989; 8(11):956-61.

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