The Role of Retinoic Acid Receptor-related Orphan Receptors in Skeletal Diseases

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2023 Nov 29

PMID 38027103

Authors

Yifan Zhang

Jun Ma

Xingfu Bao

Min Hu

Xiaoxi Wei

Affiliations

Soon will be listed here.

Abstract

Bone homeostasis, depending on the balance between bone formation and bone resorption, is responsible for maintaining the proper structure and function of the skeletal system. As an important group of transcription factors, retinoic acid receptor-related orphan receptors (RORs) have been reported to play important roles in bone homeostasis by regulating the transcription of target genes in skeletal cells. On the other hand, the dysregulation of RORs often leads to various skeletal diseases such as osteoporosis, rheumatoid arthritis (RA), and osteoarthritis (OA). Herein, we summarized the roles and mechanisms of RORs in skeletal diseases, aiming to provide evidence for potential therapeutic strategies.

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