A Transcriptomic Atlas of Acute Stress Response to Low PH in Multiple Strains

Overview

Journal Microbiol Spectr

Specialty Microbiology

Date 2023 Nov 29

PMID 38018981

Authors

Veronika Dubinkina

Shounak Bhogale

Ping-Hung Hsieh

Payam Dibaeinia

Ananthan Nambiar

Sergei Maslov

Yasuo Yoshikuni

Saurabh Sinha

Affiliations

Soon will be listed here.

Abstract

is a promising industrial chassis to produce biofuels and bioproducts due to its high tolerance to multiple environmental stresses such as low pH, heat, and other chemicals otherwise toxic for the most widely used microbes. Yet, little is known about specific mechanisms of such tolerance in this organism, hindering our ability to engineer this species to produce valuable biochemicals. Here, we report a comprehensive study of the mechanisms of acidic tolerance in this species via transcriptome profiling across variable pH for 12 different strains with different phenotypes. We found multiple regulatory mechanisms involved in tolerance to low pH in different strains of , marking potential targets for future gene editing and perturbation experiments.

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