SDF-1 Bound Heparin Nanoparticles Recruit Progenitor Cells for Their Differentiation and Promotion of Angiogenesis After Stroke

Overview

Journal Adv Healthc Mater

Specialties Biomedical Engineering
Biotechnology

Date 2023 Nov 27

PMID 38009291

Authors

Katrina L Wilson

Neica I Joseph

Lauren A Onweller

Alexa R Anderson

Nicole J Darling

Jennifer David-Bercholz

Tatiana Segura

Affiliations

Soon will be listed here.

Abstract

Angiogenesis after stroke is correlated with enhanced tissue repair and functional outcomes. The existing body of research in biomaterials for stroke focuses on hydrogels for the delivery of stem cells, growth factors, or small molecules or drugs. Despite the ability of hydrogels to enhance all these delivery methods, no material has significantly regrown vasculature within the translatable timeline of days to weeks after stroke. Here, two novel biomaterial formulations of granular hydrogels are developed for tissue regeneration after stroke: highly porous microgels (i.e., Cryo microgels) and microgels bound with heparin-norbornene nanoparticles with covalently bound SDF-1α. The combination of these materials results in perfused vessels throughout the stroke core in only 10 days, in addition to increased neural progenitor cell recruitment, maintenance, and increased neuronal differentiation.

Citing Articles

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