Growth Factors in Ischemic Stroke

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2009 Dec 18

PMID 20015202

Citations 49

Authors

S Lanfranconi

F Locatelli

S Corti

L Candelise

G P Comi

P L Baron

S Strazzer

N Bresolin

A Bersano

Affiliations

Soon will be listed here.

Abstract

Data from pre-clinical and clinical studies provide evidence that colony-stimulating factors (CSFs) and other growth factors (GFs) can improve stroke outcome by reducing stroke damage through their anti-apoptotic and anti-inflammatory effects, and by promoting angiogenesis and neurogenesis. This review provides a critical and up-to-date literature review on CSF use in stroke. We searched for experimental and clinical studies on haemopoietic GFs such as granulocyte CSF, erythropoietin, granulocyte-macrophage colony-stimulating factor, stem cell factor (SCF), vascular endothelial GF, stromal cell-derived factor-1α and SCF in ischemic stroke. We also considered studies on insulin-like growth factor-1 and neurotrophins. Despite promising results from animal models, the lack of data in human beings hampers efficacy assessments of GFs on stroke outcome. We provide a comprehensive and critical view of the present knowledge about GFs and stroke, and an overview of ongoing and future prospects.

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