A Systematic Review of Endemic to South Africa: Phytochemistry, Pharmacology, and Toxicology

Overview

Journal Life (Basel)

Specialty Biology

Date 2023 Nov 25

PMID 38004299

Authors

Maropeng Vellry Raletsena

Ofentse Jacob Pooe

Nkoana Ishmael Mongalo

Affiliations

Soon will be listed here.

Abstract

The use of traditional medicine in treating a variety of both human and animal infections is ancient and still relevant. This is due to the resistance exhibited by most pathogenic microbial stains to currently-used antibiotics. The current work reports the phytochemistry, ethno-medicinal uses, toxicology, and most important pharmacological activities that validate the use of the plant species in African traditional medicine. is used in the treatment of many human and animal infections, including diarrhea, skin and related conditions, sexually transmitted infections, cancer, and a variety of ethno-veterinary infections. Pharmacologically, the plant species exhibited potent antimicrobial activity against a variety of pathogens. Further, both extracts and compounds isolated from the plant species exhibited potent antioxidant, anticancer, anti-parasitic, anti-inflammatory, and other important biological activities. Phytochemically, the plant species possess a variety of compounds, particularly triterpenes, that may well explain the various pharmacological activities of the plant species. The toxicological parameters, antimicrobial activities against microorganisms related to sexually transmitted infections, anti-diabetic effects, and inflammatory properties of the plant species are not well studied and still need to be explored. The biological activities observed validate the use of the plant species in African traditional medicine, particularly in the treatment of pulmonary infections associated with species, and may well be due to the presence of triterpenes prevalent in the leaves.

References

Mihai M, Valentin N, Bogdan D, Carmen C, Coralia B, Demetra S . Antibiotic susceptibility profiles of Mycoplasma hominis and ureaplasma urealyticum isolated during a population-based study concerning women infertility in northeast romania. Braz J Microbiol. 2013; 42(1):256-60. PMC: 3768917. DOI: 10.1590/S1517-83822011000100032. View

Shai L, McGaw L, Aderogba M, Mdee L, Eloff J . Four pentacyclic triterpenoids with antifungal and antibacterial activity from Curtisia dentata (Burm.f) C.A. Sm. leaves. J Ethnopharmacol. 2008; 119(2):238-44. DOI: 10.1016/j.jep.2008.06.036. View

Mthethwa N, Oyedeji B, Obi L, Aiyegoro O . Anti-staphylococcal, anti-HIV and cytotoxicity studies of four South African medicinal plants and isolation of bioactive compounds from Cassine transvaalensis (Burtt. Davy) codd. BMC Complement Altern Med. 2014; 14:512. PMC: 4320432. DOI: 10.1186/1472-6882-14-512. View

Mukherjee S, Pawar N, Kulkarni O, Nagarkar B, Thopte S, Bhujbal A . Evaluation of free-radical quenching properties of standard Ayurvedic formulation Vayasthapana Rasayana. BMC Complement Altern Med. 2011; 11:38. PMC: 3123254. DOI: 10.1186/1472-6882-11-38. View

Khan M, Nahar N, Rashid R, Chowdhury A, Rashid M . Computational investigations of physicochemical, pharmacokinetic, toxicological properties and molecular docking of betulinic acid, a constituent of Corypha taliera (Roxb.) with Phospholipase A2 (PLA2). BMC Complement Altern Med. 2018; 18(1):48. PMC: 5795847. DOI: 10.1186/s12906-018-2116-x. View

Nkenfou C, Mawabo I, Notedji A, Nkenfou J, Tsouh Fokou P, Jouda J . In vitro antimycobacterial activity of six Cameroonian medicinal plants using microplate alamarBlue assay. Int J Mycobacteriol. 2016; 4(4):306-11. DOI: 10.1016/j.ijmyco.2015.08.004. View

Soyingbe O, Mongalo N, Makhafola T . In vitro antibacterial and cytotoxic activity of leaf extracts of Centella asiatica (L.) Urb, Warburgia salutaris (Bertol. F.) Chiov and Curtisia dentata (Burm. F.) C.A.Sm - medicinal plants used in South Africa. BMC Complement Altern Med. 2018; 18(1):315. PMC: 6267026. DOI: 10.1186/s12906-018-2378-3. View

Hu S, Gu F, Chen M, Wang C, Li J, Yang J . A novel method for identifying and distinguishing Cryptococcus neoformans and Cryptococcus gattii by surface-enhanced Raman scattering using positively charged silver nanoparticles. Sci Rep. 2020; 10(1):12480. PMC: 7385644. DOI: 10.1038/s41598-020-68978-0. View

Jafari F, Shokrzadeh L, Hamidian M, Salmanzadeh-Ahrabi S, Zali M . Acute diarrhea due to enteropathogenic bacteria in patients at hospitals in Tehran. Jpn J Infect Dis. 2008; 61(4):269-73. View

10.

Kuete V, Efferth T . Cameroonian medicinal plants: pharmacology and derived natural products. Front Pharmacol. 2011; 1:123. PMC: 3153003. DOI: 10.3389/fphar.2010.00123. View

11.

Oliveira-Costa J, Meira C, Neves M, Dos Reis B, Soares M . Anti-Inflammatory Activities of Betulinic Acid: A Review. Front Pharmacol. 2022; 13:883857. PMC: 9168372. DOI: 10.3389/fphar.2022.883857. View

12.

Li Z, Liu H, Li H, Dang G, Cui Z, Song N . PE17 protein from Mycobacterium tuberculosis enhances Mycobacterium smegmatis survival in macrophages and pathogenicity in mice. Microb Pathog. 2018; 126:63-73. DOI: 10.1016/j.micpath.2018.10.030. View

13.

Fernandes R, Trindade M, Tonin F, Lima C, Pugine S, Munekata P . Evaluation of antioxidant capacity of 13 plant extracts by three different methods: cluster analyses applied for selection of the natural extracts with higher antioxidant capacity to replace synthetic antioxidant in lamb burgers. J Food Sci Technol. 2016; 53(1):451-60. PMC: 4711430. DOI: 10.1007/s13197-015-1994-x. View

14.

Skiljevic D, Mirkov D, Vukicevic J . Prevalence and antibiotic susceptibility of Mycoplasma hominis and Ureaplasma urealyticum in genital samples collected over 6 years at a Serbian university hospital. Indian J Dermatol Venereol Leprol. 2016; 82(1):37-41. DOI: 10.4103/0378-6323.172903. View

15.

Patra J, Das G, Fraceto L, Campos E, Del Pilar Rodriguez-Torres M, Acosta-Torres L . Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnology. 2018; 16(1):71. PMC: 6145203. DOI: 10.1186/s12951-018-0392-8. View

16.

Langendorf C, Le Hello S, Moumouni A, Gouali M, Mamaty A, Grais R . Enteric bacterial pathogens in children with diarrhea in Niger: diversity and antimicrobial resistance. PLoS One. 2015; 10(3):e0120275. PMC: 4370739. DOI: 10.1371/journal.pone.0120275. View

17.

Baumgardner D . Fungal Infections From Human and Animal Contact. J Patient Cent Res Rev. 2019; 4(2):78-89. PMC: 6664368. DOI: 10.17294/2330-0698.1418. View

18.

Veeresham C . Natural products derived from plants as a source of drugs. J Adv Pharm Technol Res. 2013; 3(4):200-1. PMC: 3560124. DOI: 10.4103/2231-4040.104709. View

19.

Opoku A, Maseko N, Terblanche S . The in vitro antioxidative activity of some traditional Zulu medicinal plants. Phytother Res. 2002; 16 Suppl 1:S51-6. DOI: 10.1002/ptr.804. View

20.

Oyedemi S, Oyedemi B, Arowosegbe S, Afolayan A . Phytochemicals analysis and medicinal potentials of hydroalcoholic extract from Curtisia dentata (Burm.f) C.A. Sm Stem Bark. Int J Mol Sci. 2012; 13(5):6189-6203. PMC: 3382764. DOI: 10.3390/ijms13056189. View