Plant-derived Nanovesicles: Harnessing Nature's Power for Tissue Protection and Repair

Overview

Journal J Nanobiotechnology

Publisher Biomed Central

Specialty Biotechnology

Date 2023 Nov 24

PMID 38001440

Authors

Xiaohang Chen

Xiaojie Xing

Shuoqi Lin

Liyu Huang

Lianghang He

Yuchun Zou

Xuyang Zhang

Bohua Su

Youguang Lu

Dali Zheng

Affiliations

Soon will be listed here.

Abstract

Tissue damage and aging lead to dysfunction, disfigurement, and trauma, posing significant global challenges. Creating a regenerative microenvironment to resist external stimuli and induce stem cell differentiation is essential. Plant-derived nanovesicles (PDNVs) are naturally bioactive lipid bilayer nanovesicles that contain proteins, lipids, ribonucleic acid, and metabolites. They have shown potential in promoting cell growth, migration, and differentiation into various types of tissues. With immunomodulatory, microbiota regulatory, antioxidant, and anti-aging bioactivities, PDNVs are valuable in resisting external stimuli and facilitating tissue repair. The unique structure of PDNVs provides an optimal platform for drug encapsulation, and surface modifications enhance their stability and specificity. Moreover, by employing synergistic administration strategies, PDNVs can maximize their therapeutic potential. This review summarized the progress and prospects of PDNVs as regenerative tools, provided insights into their selection for repair activities based on existing studies, considered the key challenge for clinical application, and anticipated their continued prominent role in the field of biomedicine.

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References

L L, X W, Z Y . Ischemia-reperfusion Injury in the Brain: Mechanisms and Potential Therapeutic Strategies. Biochem Pharmacol (Los Angel). 2018; 5(4). PMC: 5991620. DOI: 10.4172/2167-0501.1000213. View

Liu C, Yan X, Zhang Y, Yang M, Ma Y, Zhang Y . Oral administration of turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving bioactions for murine colitis therapy. J Nanobiotechnology. 2022; 20(1):206. PMC: 9052603. DOI: 10.1186/s12951-022-01421-w. View

Sundaram K, Mu J, Kumar A, Behera J, Lei C, Sriwastva M . Garlic exosome-like nanoparticles reverse high-fat diet induced obesity via the gut/brain axis. Theranostics. 2022; 12(3):1220-1246. PMC: 8771565. DOI: 10.7150/thno.65427. View

Fang Z, Liu K . Plant-derived extracellular vesicles as oral drug delivery carriers. J Control Release. 2022; 350:389-400. DOI: 10.1016/j.jconrel.2022.08.046. View

Cai J, Pan J . Beta vulgaris-derived exosome-like nanovesicles alleviate chronic doxorubicin-induced cardiotoxicity by inhibiting ferroptosis. J Biochem Mol Toxicol. 2023; 38(1):e23540. DOI: 10.1002/jbt.23540. View

Xu Z, Xu Y, Zhang K, Liu Y, Liang Q, Thakur A . Plant-derived extracellular vesicles (PDEVs) in nanomedicine for human disease and therapeutic modalities. J Nanobiotechnology. 2023; 21(1):114. PMC: 10049910. DOI: 10.1186/s12951-023-01858-7. View

Sharifi-Rad M, Anil Kumar N, Zucca P, Varoni E, Dini L, Panzarini E . Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases. Front Physiol. 2020; 11:694. PMC: 7347016. DOI: 10.3389/fphys.2020.00694. View

Deng Z, Rong Y, Teng Y, Mu J, Zhuang X, Tseng M . Broccoli-Derived Nanoparticle Inhibits Mouse Colitis by Activating Dendritic Cell AMP-Activated Protein Kinase. Mol Ther. 2017; 25(7):1641-1654. PMC: 5498816. DOI: 10.1016/j.ymthe.2017.01.025. View

Schuh C, Aguayo S, Zavala G, Khoury M . Exosome-like vesicles in bee pollen, honey and royal jelly contribute to their antibacterial and pro-regenerative activity. J Exp Biol. 2019; 222(Pt 20). DOI: 10.1242/jeb.208702. View

10.

Brennan M, Layrolle P, Mooney D . Biomaterials functionalized with MSC secreted extracellular vesicles and soluble factors for tissue regeneration. Adv Funct Mater. 2020; 30(37). PMC: 7494127. DOI: 10.1002/adfm.201909125. View

11.

Cao M, Yan H, Han X, Weng L, Wei Q, Sun X . Ginseng-derived nanoparticles alter macrophage polarization to inhibit melanoma growth. J Immunother Cancer. 2019; 7(1):326. PMC: 6882204. DOI: 10.1186/s40425-019-0817-4. View

12.

Kim W, Ha J, Jeong S, Lee J, Lee B, Jeong Y . Immunological Effects of Callus-Derived Extracellular Vesicles as Potential Therapeutic Agents against Allergic Asthma. Cells. 2022; 11(18). PMC: 9497061. DOI: 10.3390/cells11182805. View

13.

Wang Q, Ren Y, Mu J, Egilmez N, Zhuang X, Deng Z . Grapefruit-Derived Nanovectors Use an Activated Leukocyte Trafficking Pathway to Deliver Therapeutic Agents to Inflammatory Tumor Sites. Cancer Res. 2015; 75(12):2520-9. PMC: 4470740. DOI: 10.1158/0008-5472.CAN-14-3095. View

14.

Triantafillidis J, Merikas E, Georgopoulos F . Current and emerging drugs for the treatment of inflammatory bowel disease. Drug Des Devel Ther. 2011; 5:185-210. PMC: 3084301. DOI: 10.2147/DDDT.S11290. View

15.

Manzaneque-Lopez M, Sanchez-Lopez C, Perez-Bermudez P, Soler C, Marcilla A . Dietary-Derived Exosome-like Nanoparticles as Bacterial Modulators: Beyond MicroRNAs. Nutrients. 2023; 15(5). PMC: 10005434. DOI: 10.3390/nu15051265. View

16.

Liu B, Lu Y, Chen X, Muthuraj P, Li X, Pattabiraman M . Protective Role of Shiitake Mushroom-Derived Exosome-Like Nanoparticles in D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice. Nutrients. 2020; 12(2). PMC: 7071144. DOI: 10.3390/nu12020477. View

17.

Liu B, Li X, Yu H, Shi X, Zhou Y, Alvarez S . Therapeutic potential of garlic chive-derived vesicle-like nanoparticles in NLRP3 inflammasome-mediated inflammatory diseases. Theranostics. 2021; 11(19):9311-9330. PMC: 8490522. DOI: 10.7150/thno.60265. View

18.

Zhang M, Wang X, Han M, Collins J, Merlin D . Oral administration of ginger-derived nanolipids loaded with siRNA as a novel approach for efficient siRNA drug delivery to treat ulcerative colitis. Nanomedicine (Lond). 2017; 12(16):1927-1943. PMC: 5827822. DOI: 10.2217/nnm-2017-0196. View

19.

Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J . Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2018; 9(6):7204-7218. PMC: 5805548. DOI: 10.18632/oncotarget.23208. View

20.

Xu X, Yuan T, Dad H, Shi M, Huang Y, Jiang Z . Plant Exosomes As Novel Nanoplatforms for MicroRNA Transfer Stimulate Neural Differentiation of Stem Cells In Vitro and In Vivo. Nano Lett. 2021; 21(19):8151-8159. DOI: 10.1021/acs.nanolett.1c02530. View