Plant-derived Extracellular Vesicles (PDEVs) in Nanomedicine for Human Disease and Therapeutic Modalities

Overview

Journal J Nanobiotechnology

Publisher Biomed Central

Specialty Biotechnology

Date 2023 Mar 28

PMID 36978093

Authors

Zhijie Xu

Yuzhen Xu

Kui Zhang

Yuanhong Liu

Qiuju Liang

Abhimanyu Thakur

Wei Liu

Yuanliang Yan

Affiliations

Soon will be listed here.

Abstract

Background: The past few years have witnessed a significant increase in research related to plant-derived extracellular vesicles (PDEVs) in biological and medical applications. Using biochemical technologies, multiple independent groups have demonstrated the important roles of PDEVs as potential mediators involved in cell-cell communication and the exchange of bio-information between species. Recently, several contents have been well identified in PDEVs, including nucleic acids, proteins, lipids, and other active substances. These cargoes carried by PDEVs could be transferred into recipient cells and remarkably influence their biological behaviors associated with human diseases, such as cancers and inflammatory diseases. This review summarizes the latest updates regarding PDEVs and focuses on its important role in nanomedicine applications, as well as the potential of PDEVs as drug delivery strategies to develop diagnostic and therapeutic agents for the clinical management of diseases, especially like cancers.

Conclusion: Considering its unique advantages, especially high stability, intrinsic bioactivity and easy absorption, further elaboration on molecular mechanisms and biological factors driving the function of PDEVs will provide new horizons for the treatment of human disease.

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References

Kim S, Kim K . Emergence of Edible Plant-Derived Nanovesicles as Functional Food Components and Nanocarriers for Therapeutics Delivery: Potentials in Human Health and Disease. Cells. 2022; 11(14). PMC: 9319657. DOI: 10.3390/cells11142232. View

Savci Y, Kirbas O, Bozkurt B, Avsar Abdik E, Tasli P, Sahin F . Grapefruit-derived extracellular vesicles as a promising cell-free therapeutic tool for wound healing. Food Funct. 2021; 12(11):5144-5156. DOI: 10.1039/d0fo02953j. View

Roy M, Yang Y, Bosquet O, Deo S, Daunert S . Understanding the Role and Clinical Applications of Exosomes in Gynecologic Malignancies: A Review of the Current Literature. Cancers (Basel). 2022; 14(1). PMC: 8750967. DOI: 10.3390/cancers14010158. View

Zhang Y, Cai Z, Shen Y, Lu Q, Gao W, Zhong X . Hydrogel-load exosomes derived from dendritic cells improve cardiac function via Treg cells and the polarization of macrophages following myocardial infarction. J Nanobiotechnology. 2021; 19(1):271. PMC: 8424987. DOI: 10.1186/s12951-021-01016-x. View

Almasabi S, Ahmed A, Boyd R, Williams B . A Potential Role for Integrin-Linked Kinase in Colorectal Cancer Growth and Progression via Regulating Senescence and Immunity. Front Genet. 2021; 12:638558. PMC: 8216764. DOI: 10.3389/fgene.2021.638558. View

Jackson K, Mata C, Marcus R . A rapid capillary-channeled polymer (C-CP) fiber spin-down tip approach for the isolation of plant-derived extracellular vesicles (PDEVs) from 20 common fruit and vegetable sources. Talanta. 2022; 252:123779. DOI: 10.1016/j.talanta.2022.123779. View

Kim K, Park J, Sohn Y, Oh C, Park J, Yuk J . Stability of Plant Leaf-Derived Extracellular Vesicles According to Preservative and Storage Temperature. Pharmaceutics. 2022; 14(2). PMC: 8879201. DOI: 10.3390/pharmaceutics14020457. View

Narauskaite D, Vydmantaite G, Rusteikaite J, Sampath R, Rudaityte A, Stasyte G . Extracellular Vesicles in Skin Wound Healing. Pharmaceuticals (Basel). 2021; 14(8). PMC: 8400229. DOI: 10.3390/ph14080811. View

Cong M, Tan S, Li S, Gao L, Huang L, Zhang H . Technology insight: Plant-derived vesicles-How far from the clinical biotherapeutics and therapeutic drug carriers?. Adv Drug Deliv Rev. 2022; 182:114108. DOI: 10.1016/j.addr.2021.114108. View

10.

Fang Z, Liu K . Plant-derived extracellular vesicles as oral drug delivery carriers. J Control Release. 2022; 350:389-400. DOI: 10.1016/j.jconrel.2022.08.046. View

11.

Kocholata M, Prusova M, Auer Malinska H, Maly J, Janouskova O . Comparison of two isolation methods of tobacco-derived extracellular vesicles, their characterization and uptake by plant and rat cells. Sci Rep. 2022; 12(1):19896. PMC: 9674704. DOI: 10.1038/s41598-022-23961-9. View

12.

Urzi O, Gasparro R, Rabienezhad Ganji N, Alessandro R, Raimondo S . Plant-RNA in Extracellular Vesicles: The Secret of Cross-Kingdom Communication. Membranes (Basel). 2022; 12(4). PMC: 9028404. DOI: 10.3390/membranes12040352. View

13.

Yang M, Liu X, Luo Q, Xu L, Chen F . An efficient method to isolate lemon derived extracellular vesicles for gastric cancer therapy. J Nanobiotechnology. 2020; 18(1):100. PMC: 7370524. DOI: 10.1186/s12951-020-00656-9. View

14.

Logozzi M, Di Raimo R, Mizzoni D, Fais S . The Potentiality of Plant-Derived Nanovesicles in Human Health-A Comparison with Human Exosomes and Artificial Nanoparticles. Int J Mol Sci. 2022; 23(9). PMC: 9101147. DOI: 10.3390/ijms23094919. View

15.

Cao M, Yan H, Han X, Weng L, Wei Q, Sun X . Ginseng-derived nanoparticles alter macrophage polarization to inhibit melanoma growth. J Immunother Cancer. 2019; 7(1):326. PMC: 6882204. DOI: 10.1186/s40425-019-0817-4. View

16.

Kim W, Ha J, Jeong S, Lee J, Lee B, Jeong Y . Immunological Effects of Callus-Derived Extracellular Vesicles as Potential Therapeutic Agents against Allergic Asthma. Cells. 2022; 11(18). PMC: 9497061. DOI: 10.3390/cells11182805. View

17.

Li D, Yang M, Xu H, Zhu M, Zhang Y, Tian C . Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease. J Mater Chem B. 2022; 10(31):5853-5872. DOI: 10.1039/d2tb01190e. View

18.

Huang C, Liu Z, Chen M, Du L, Liu C, Wang S . Tumor-derived biomimetic nanozyme with immune evasion ability for synergistically enhanced low dose radiotherapy. J Nanobiotechnology. 2021; 19(1):457. PMC: 8715603. DOI: 10.1186/s12951-021-01182-y. View

19.

Wang Q, Ren Y, Mu J, Egilmez N, Zhuang X, Deng Z . Grapefruit-Derived Nanovectors Use an Activated Leukocyte Trafficking Pathway to Deliver Therapeutic Agents to Inflammatory Tumor Sites. Cancer Res. 2015; 75(12):2520-9. PMC: 4470740. DOI: 10.1158/0008-5472.CAN-14-3095. View

20.

Suharta S, Barlian A, Hidajah A, Notobroto H, Ana I, Indariani S . Plant-derived exosome-like nanoparticles: A concise review on its extraction methods, content, bioactivities, and potential as functional food ingredient. J Food Sci. 2021; 86(7):2838-2850. DOI: 10.1111/1750-3841.15787. View