Epstein-Barr Virus and Host Cell 3D Genome Organization

Overview

Journal J Med Virol

Specialty Microbiology

Date 2023 Nov 21

PMID 37988227

Authors

Chong Wang

Bo Zhao

Affiliations

Soon will be listed here.

Abstract

The human genome is organized in an extremely complexed yet ordered way within the nucleus. Genome organization plays a critical role in the regulation of gene expression. Viruses manipulate the host machinery to influence host genome organization to favor their survival and promote disease development. Epstein-Barr virus (EBV) is a common human virus, whose infection is associated with various diseases, including infectious mononucleosis, cancer, and autoimmune disorders. This review summarizes our current knowledge of how EBV uses different strategies to control the cellular 3D genome organization to affect cell gene expression to transform normal cells into lymphoblasts.

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