Metastasis Suppressor Genes and Their Role in the Tumor Microenvironment

Overview

Journal Cancer Metastasis Rev

Specialty Oncology

Date 2023 Nov 20

PMID 37982987

Authors

Cristina Megino-Luque

Jose Javier Bravo-Cordero

Affiliations

Soon will be listed here.

Abstract

The metastatic cascade is a complex process with multiple factors contributing to the seeding and growth of cancer cells at metastatic sites. Within this complex process, several genes have been identified as metastasis suppressors, playing a role in the inhibition of metastasis. Interestingly, some of these genes have been shown to also play a role in regulating the tumor microenvironment. In this review, we comment on the recent developments in the biology of metastasis suppressor genes and their crosstalk with the microenvironment.

Citing Articles

TNNT1 accelerates migration, invasion and EMT progression in lung cancer cells.

Ge X, Du G, Zhou Q, Yan B, Yue G Thorac Cancer. 2024; 15(23):1749-1756.

PMID: 38973201 PMC: 11320084. DOI: 10.1111/1759-7714.15400.

References

Knopeke M, Ritschdorff E, Clark R, Vander Griend D, Khan S, Thobe M . Building on the foundation of daring hypotheses: using the MKK4 metastasis suppressor to develop models of dormancy and metastatic colonization. FEBS Lett. 2011; 585(20):3159-65. DOI: 10.1016/j.febslet.2011.09.007. View

Harihar S, Ray S, Narayanan S, Santhoshkumar A, Ly T, Welch D . Role of the tumor microenvironment in regulating the anti-metastatic effect of KISS1. Clin Exp Metastasis. 2020; 37(2):209-223. PMC: 7339126. DOI: 10.1007/s10585-020-10030-6. View

Mukherjee A, Bravo-Cordero J . Regulation of dormancy during tumor dissemination: the role of the ECM. Cancer Metastasis Rev. 2023; 42(1):99-112. PMC: 10027413. DOI: 10.1007/s10555-023-10094-2. View

Klein C . Parallel progression of primary tumours and metastases. Nat Rev Cancer. 2009; 9(4):302-12. DOI: 10.1038/nrc2627. View

LInde N, Casanova-Acebes M, Sosa M, Mortha A, Rahman A, Farias E . Macrophages orchestrate breast cancer early dissemination and metastasis. Nat Commun. 2018; 9(1):21. PMC: 5750231. DOI: 10.1038/s41467-017-02481-5. View

Gligorijevic B, Wyckoff J, Yamaguchi H, Wang Y, Roussos E, Condeelis J . N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors. J Cell Sci. 2012; 125(Pt 3):724-34. PMC: 3367832. DOI: 10.1242/jcs.092726. View

Schoentgen F, Jonic S . PEBP1/RKIP behavior: a mirror of actin-membrane organization. Cell Mol Life Sci. 2020; 77(5):859-874. PMC: 11105014. DOI: 10.1007/s00018-020-03455-5. View

Sosa M, Parikh F, Gaspar Maia A, Estrada Y, Bosch A, Bragado P . NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes. Nat Commun. 2015; 6:6170. PMC: 4313575. DOI: 10.1038/ncomms7170. View

Mondal C, Gacha-Garay M, Larkin K, Adikes R, Di Martino J, Chien C . A proliferative to invasive switch is mediated by srGAP1 downregulation through the activation of TGF-β2 signaling. Cell Rep. 2022; 40(12):111358. PMC: 9596226. DOI: 10.1016/j.celrep.2022.111358. View

10.

Giancotti F . Mechanisms governing metastatic dormancy and reactivation. Cell. 2013; 155(4):750-64. PMC: 4354734. DOI: 10.1016/j.cell.2013.10.029. View

11.

Risson E, Nobre A, Maguer-Satta V, Aguirre-Ghiso J . The current paradigm and challenges ahead for the dormancy of disseminated tumor cells. Nat Cancer. 2021; 1(7):672-680. PMC: 7929485. DOI: 10.1038/s43018-020-0088-5. View

12.

Lin E, Pollard J . Macrophages: modulators of breast cancer progression. Novartis Found Symp. 2004; 256:158-68. View

13.

Harding M, Theodorescu D . RhoGDI2: a new metastasis suppressor gene: discovery and clinical translation. Urol Oncol. 2007; 25(5):401-6. DOI: 10.1016/j.urolonc.2007.05.006. View

14.

Ray A, Callaway M, Rodriguez-Merced N, Crampton A, Carlson M, Emme K . Stromal architecture directs early dissemination in pancreatic ductal adenocarcinoma. JCI Insight. 2021; 7(3). PMC: 8855836. DOI: 10.1172/jci.insight.150330. View

15.

Ly T, Harihar S, Welch D . KISS1 in metastatic cancer research and treatment: potential and paradoxes. Cancer Metastasis Rev. 2020; 39(3):739-754. PMC: 7483209. DOI: 10.1007/s10555-020-09868-9. View

16.

Kang Y, Pantel K . Tumor cell dissemination: emerging biological insights from animal models and cancer patients. Cancer Cell. 2013; 23(5):573-81. PMC: 3667710. DOI: 10.1016/j.ccr.2013.04.017. View

17.

Vennin C, Herrmann D, Lucas M, Timpson P . Intravital imaging reveals new ancillary mechanisms co-opted by cancer cells to drive tumor progression. F1000Res. 2016; 5. PMC: 4870995. DOI: 10.12688/f1000research.8090.1. View

18.

Quail D, Joyce J . Microenvironmental regulation of tumor progression and metastasis. Nat Med. 2013; 19(11):1423-37. PMC: 3954707. DOI: 10.1038/nm.3394. View

19.

Hur J, Choi J, Lee H, Nham P, Kim T, Chae C . CD82/KAI1 Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through Interaction with DARC-Expressing Macrophages. Cell Stem Cell. 2016; 18(4):508-21. DOI: 10.1016/j.stem.2016.01.013. View

20.

Massague J, Obenauf A . Metastatic colonization by circulating tumour cells. Nature. 2016; 529(7586):298-306. PMC: 5029466. DOI: 10.1038/nature17038. View