Tumor Cell Dissemination: Emerging Biological Insights from Animal Models and Cancer Patients

Overview

Journal Cancer Cell

Publisher Cell Press

Specialty Oncology

Date 2013 May 18

PMID 23680145

Citations 216

Authors

Yibin Kang

Klaus Pantel

Affiliations

Soon will be listed here.

Abstract

Circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) are increasingly recognized for their potential utility in disease monitoring and therapeutic targeting. The clinical application of CTC/DTC requires better understanding of the biological mechanisms behind tumor dissemination, the survival of DTCs, and their activation to aggressive growth from dormancy. Recent research using animal models of DTCs and CTCs have provided novel insights into these processes. Here, we discuss these findings in the context of results obtained from the clinical analyses of CTCs and DTCs, which demonstrate that the animal models mimic, in many aspects, the complex situation in patients.

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References

Dunn L, Mohammad K, Fournier P, McKenna C, Davis H, Niewolna M . Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment. PLoS One. 2009; 4(9):e6896. PMC: 2731927. DOI: 10.1371/journal.pone.0006896. View

Vega S, Morales A, Ocana O, Valdes F, Fabregat I, Nieto M . Snail blocks the cell cycle and confers resistance to cell death. Genes Dev. 2004; 18(10):1131-43. PMC: 415638. DOI: 10.1101/gad.294104. View

Pantel K, Schlimok G, Braun S, Kutter D, Lindemann F, Schaller G . Differential expression of proliferation-associated molecules in individual micrometastatic carcinoma cells. J Natl Cancer Inst. 1993; 85(17):1419-24. DOI: 10.1093/jnci/85.17.1419. View

Thiery J, Acloque H, Huang R, Nieto M . Epithelial-mesenchymal transitions in development and disease. Cell. 2009; 139(5):871-90. DOI: 10.1016/j.cell.2009.11.007. View

Korpal M, Ell B, Buffa F, Ibrahim T, Blanco M, Celia-Terrassa T . Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med. 2011; 17(9):1101-8. PMC: 3169707. DOI: 10.1038/nm.2401. View

Gao H, Chakraborty G, Lee-Lim A, Mo Q, Decker M, Vonica A . The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites. Cell. 2012; 150(4):764-79. PMC: 3711709. DOI: 10.1016/j.cell.2012.06.035. View

Ocana O, Corcoles R, Fabra A, Moreno-Bueno G, Acloque H, Vega S . Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. Cancer Cell. 2012; 22(6):709-24. DOI: 10.1016/j.ccr.2012.10.012. View

Janni W, Vogl F, Wiedswang G, Synnestvedt M, Fehm T, Juckstock J . Persistence of disseminated tumor cells in the bone marrow of breast cancer patients predicts increased risk for relapse--a European pooled analysis. Clin Cancer Res. 2011; 17(9):2967-76. DOI: 10.1158/1078-0432.CCR-10-2515. View

Sosa M, Avivar-Valderas A, Bragado P, Wen H, Aguirre-Ghiso J . ERK1/2 and p38α/β signaling in tumor cell quiescence: opportunities to control dormant residual disease. Clin Cancer Res. 2011; 17(18):5850-7. PMC: 3226348. DOI: 10.1158/1078-0432.CCR-10-2574. View

10.

Mani S, Guo W, Liao M, Eaton E, Ayyanan A, Zhou A . The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 2008; 133(4):704-15. PMC: 2728032. DOI: 10.1016/j.cell.2008.03.027. View

11.

Mani S, Yang J, Brooks M, Schwaninger G, Zhou A, Miura N . Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci U S A. 2007; 104(24):10069-74. PMC: 1891217. DOI: 10.1073/pnas.0703900104. View

12.

Steeg P . Heterogeneity of drug target expression among metastatic lesions: lessons from a breast cancer autopsy program. Clin Cancer Res. 2008; 14(12):3643-5. PMC: 2692037. DOI: 10.1158/1078-0432.CCR-08-1135. View

13.

van de Wouw A, Janssen-Heijnen M, Coebergh J, Hillen H . Epidemiology of unknown primary tumours; incidence and population-based survival of 1285 patients in Southeast Netherlands, 1984-1992. Eur J Cancer. 2002; 38(3):409-13. DOI: 10.1016/s0959-8049(01)00378-1. View

14.

Brabletz T . To differentiate or not--routes towards metastasis. Nat Rev Cancer. 2012; 12(6):425-36. DOI: 10.1038/nrc3265. View

15.

Bidwell B, Slaney C, Withana N, Forster S, Cao Y, Loi S . Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape. Nat Med. 2012; 18(8):1224-31. DOI: 10.1038/nm.2830. View

16.

Lin K, Lu D, Hung C, Peng S, Huang L, Jie C . Ectopic expression of vascular cell adhesion molecule-1 as a new mechanism for tumor immune evasion. Cancer Res. 2007; 67(4):1832-41. PMC: 3172051. DOI: 10.1158/0008-5472.CAN-06-3014. View

17.

Muller V, Stahmann N, Riethdorf S, Rau T, Zabel T, Goetz A . Circulating tumor cells in breast cancer: correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activity. Clin Cancer Res. 2005; 11(10):3678-85. DOI: 10.1158/1078-0432.CCR-04-2469. View

18.

Chen Q, Zhang X, Massague J . Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs. Cancer Cell. 2011; 20(4):538-49. PMC: 3293160. DOI: 10.1016/j.ccr.2011.08.025. View

19.

Francia G, Cruz-Munoz W, Man S, Xu P, Kerbel R . Mouse models of advanced spontaneous metastasis for experimental therapeutics. Nat Rev Cancer. 2011; 11(2):135-41. PMC: 4540342. DOI: 10.1038/nrc3001. View

20.

Riethdorf S, Muller V, Zhang L, Rau T, Loibl S, Komor M . Detection and HER2 expression of circulating tumor cells: prospective monitoring in breast cancer patients treated in the neoadjuvant GeparQuattro trial. Clin Cancer Res. 2010; 16(9):2634-45. DOI: 10.1158/1078-0432.CCR-09-2042. View