Quantitative Measurement of Influenza Virus Transmission in Animal Model: an Overview of Current State

Overview

Journal Biophys Rev

Publisher Springer

Specialty Biophysics

Date 2023 Nov 17

PMID 37975001

Authors

Galina Onkhonova

Andrei Gudymo

Maksim Kosenko

Vasiliy Marchenko

Alexander Ryzhikov

Affiliations

Soon will be listed here.

Abstract

Influenza virus transmission is a crucial factor in understanding the spread of the virus within populations and developing effective control strategies. Studying the transmission patterns of influenza virus allows for better risk assessment and prediction of disease outbreaks. By monitoring the spread of the virus and identifying high-risk populations and geographic areas, it is possible to allocate resources more effectively, implement timely interventions, and provide targeted healthcare interventions to diminish the burden of influenza virus on vulnerable populations. Theoretical models of virus transmission are used to study and simulate of influenza virus spread within populations. These models aim to capture the complex dynamics of transmission, including factors such as population size, contact patterns, infectiousness, and susceptibility. Animal models serve as valuable tools for studying the dynamics of influenza virus transmission. This article presents a brief overview of existing research on the qualitative and quantitative study of influenza virus transmission in animal models. We discuss the methodologies employed, key insights gained from these studies, and their relevance.

Citing Articles

VII Congress of Russian Biophysicists-2023, Krasnodar, Russia.

Anashkina A, Rubin A, Gudimchuk N, Vanin A, Tsygankov A, Orlov Y Biophys Rev. 2023; 15(5):801-805.

PMID: 37975012 PMC: 10643460. DOI: 10.1007/s12551-023-01164-4.

References

Tripp R, Tompkins S . Animal models for evaluation of influenza vaccines. Curr Top Microbiol Immunol. 2009; 333:397-412. DOI: 10.1007/978-3-540-92165-3_19. View

EATON M . Transmission of Epidemic Influenza Virus in Mice by Contact. J Bacteriol. 1940; 39(3):229-41. PMC: 374567. DOI: 10.1128/jb.39.3.229-241.1940. View

Pulit-Penaloza J, Brock N, Belser J, Sun X, Pappas C, Tumpey T . Kinetics and magnitude of viral RNA shedding as indicators for Influenza A virus transmissibility in ferrets. Commun Biol. 2023; 6(1):90. PMC: 9871019. DOI: 10.1038/s42003-023-04459-0. View

Zhang H, Li X, Ma R, Li X, Zhou Y, Dong H . Airborne spread and infection of a novel swine-origin influenza A (H1N1) virus. Virol J. 2013; 10:204. PMC: 3700749. DOI: 10.1186/1743-422X-10-204. View

Smith D, McKenzie F, Snow R, Hay S . Revisiting the basic reproductive number for malaria and its implications for malaria control. PLoS Biol. 2007; 5(3):e42. PMC: 1802755. DOI: 10.1371/journal.pbio.0050042. View

Su S, Tian J, Hong M, Zhou P, Lu G, Zhu H . Global and quantitative proteomic analysis of dogs infected by avian-like H3N2 canine influenza virus. Front Microbiol. 2015; 6:228. PMC: 4382988. DOI: 10.3389/fmicb.2015.00228. View

Danzy S, Lowen A, Steel J . A quantitative approach to assess influenza A virus fitness and transmission in guinea pigs. J Virol. 2021; 95(11). PMC: 8139685. DOI: 10.1128/JVI.02320-20. View

Ito T, Couceiro J, Kelm S, Baum L, Krauss S, Castrucci M . Molecular basis for the generation in pigs of influenza A viruses with pandemic potential. J Virol. 1998; 72(9):7367-73. PMC: 109961. DOI: 10.1128/JVI.72.9.7367-7373.1998. View

Bao L, Xu L, Zhu H, Deng W, Chen T, Lv Q . Transmission of H7N9 influenza virus in mice by different infective routes. Virol J. 2014; 11:185. PMC: 4289364. DOI: 10.1186/1743-422X-11-185. View

10.

Bertran K, Balzli C, Kwon Y, Tumpey T, Clark A, Swayne D . Airborne Transmission of Highly Pathogenic Influenza Virus during Processing of Infected Poultry. Emerg Infect Dis. 2017; 23(11):1806-1814. PMC: 5652435. DOI: 10.3201/eid2311.170672. View

11.

Voorhees I, Glaser A, Toohey-Kurth K, Newbury S, Dalziel B, Dubovi E . Spread of Canine Influenza A(H3N2) Virus, United States. Emerg Infect Dis. 2017; 23(12):1950-1957. PMC: 5708240. DOI: 10.3201/eid2312.170246. View

12.

Lowen A, Mubareka S, Tumpey T, Garcia-Sastre A, Palese P . The guinea pig as a transmission model for human influenza viruses. Proc Natl Acad Sci U S A. 2006; 103(26):9988-92. PMC: 1502566. DOI: 10.1073/pnas.0604157103. View

13.

Allerson M, Cardona C, Torremorell M . Indirect Transmission of Influenza A Virus between Pig Populations under Two Different Biosecurity Settings. PLoS One. 2013; 8(6):e67293. PMC: 3689715. DOI: 10.1371/journal.pone.0067293. View

14.

Asadi S, Gaaloul Ben Hnia N, Barre R, Wexler A, Ristenpart W, Bouvier N . Influenza A virus is transmissible via aerosolized fomites. Nat Commun. 2020; 11(1):4062. PMC: 7435178. DOI: 10.1038/s41467-020-17888-w. View

15.

Ibricevic A, Pekosz A, Walter M, Newby C, Battaile J, Brown E . Influenza virus receptor specificity and cell tropism in mouse and human airway epithelial cells. J Virol. 2006; 80(15):7469-80. PMC: 1563738. DOI: 10.1128/JVI.02677-05. View

16.

Edenborough K, Gilbertson B, Brown L . A mouse model for the study of contact-dependent transmission of influenza A virus and the factors that govern transmissibility. J Virol. 2012; 86(23):12544-51. PMC: 3497676. DOI: 10.1128/JVI.00859-12. View

17.

Kuiken T, Rimmelzwaan G, van Riel D, van Amerongen G, Baars M, Fouchier R . Avian H5N1 influenza in cats. Science. 2004; 306(5694):241. DOI: 10.1126/science.1102287. View

18.

Lange E, Kalthoff D, Blohm U, Teifke J, Breithaupt A, Maresch C . Pathogenesis and transmission of the novel swine-origin influenza virus A/H1N1 after experimental infection of pigs. J Gen Virol. 2009; 90(Pt 9):2119-23. DOI: 10.1099/vir.0.014480-0. View

19.

Sponseller B, Strait E, Jergens A, Trujillo J, Harmon K, Koster L . Influenza A pandemic (H1N1) 2009 virus infection in domestic cat. Emerg Infect Dis. 2010; 16(3):534-7. PMC: 3322044. DOI: 10.3201/eid1603.091737. View

20.

Lohr C, DeBess E, Baker R, Hiett S, Hoffman K, Murdoch V . Pathology and viral antigen distribution of lethal pneumonia in domestic cats due to pandemic (H1N1) 2009 influenza A virus. Vet Pathol. 2010; 47(3):378-86. PMC: 4165647. DOI: 10.1177/0300985810368393. View