» Articles » PMID: 37960197

Causality Investigation Between Gut Microbiota, Derived Metabolites, and Obstructive Sleep Apnea: A Bidirectional Mendelian Randomization Study

Overview
Journal Nutrients
Date 2023 Nov 14
PMID 37960197
Authors
Affiliations
Soon will be listed here.
Abstract

Various studies have highlighted the important associations between obstructive sleep apnea (OSA) and gut microbiota and related metabolites. Nevertheless, the establishment of causal relationships between these associations remains to be determined. Multiple mendelian randomization (MR) analyses were performed to genetically predict the causative impact of 196 gut microbiota and 83 metabolites on OSA. Two-sample MR was used to assess the potential association, and causality was evaluated using inverse variance weighted (IVW), MR-Egger, and weighted median (WM) methods. Multivariable MR (MVMR) was employed to ascertain the causal independence between gut microbiota and the metabolites linked to OSA. Additionally, Cochran's Q test, the MR Egger intercept test and the MR Steiger test were used for the sensitivity analyses. The analysis of the 196 gut microbiota revealed that _ () (P = 0.010) and _ (P = 0.041) were associated with an increased risk of OSA onset. Conversely, _ (P = 0.030), _ (P = 0.025), _ (P = 0.011), and _ (_) (P = 0.001) were negatively related to the risk of OSA. Among the 83 metabolites evaluated, 3-dehydrocarnitine, epiandrosterone sulfate, and leucine were determined to be potential independent risk factors associated with OSA. Moreover, the reverse MR analysis demonstrated a suggestive association between OSA exposure and six microbiota taxa. This study offers compelling evidence regarding the potential beneficial or detrimental causative impact of the gut microbiota and its associated metabolites on OSA risk, thereby providing new insights into the mechanisms of gut microbiome-mediated OSA development.

Citing Articles

Mendelian randomization analysis to identify potential drug targets for osteoarthritis.

Lu C, Xu Y, Chen S, Guo L, Li P, Wei X PLoS One. 2025; 20(2):e0316824.

PMID: 39932908 PMC: 11813149. DOI: 10.1371/journal.pone.0316824.


Better objective sleep quality is associated with higher gut microbiota richness in older adults.

Wijaya M, Fang J, Liu G, Yeh Y, Chen N, Lin C Geroscience. 2025; .

PMID: 39888583 DOI: 10.1007/s11357-025-01524-w.


Role of metabolic characteristics in the co-occurrence of insomnia, Alzheimer's disease, and Parkinson's disease: a Mendelian randomization study.

Liu C, Wang C, Jiang J, Bo Y, Nan L, Zhang Y Front Aging Neurosci. 2025; 16():1436171.

PMID: 39834620 PMC: 11743693. DOI: 10.3389/fnagi.2024.1436171.


The role of the microbiota-gut-brain axis and artificial intelligence in cognitive health of pediatric obstructive sleep apnea: A narrative review.

Lv Y, Xian Y, Lei X, Xie S, Zhang B Medicine (Baltimore). 2024; 103(50):e40900.

PMID: 39686454 PMC: 11651515. DOI: 10.1097/MD.0000000000040900.


Dysbiosis of gut microbiota is associated with pathogenesis of peptic ulcer diseases through inflammatory proteins: A Mendelian randomization study.

Li J, Cai H, Zhang Y, Li J, Wang D, Li H Medicine (Baltimore). 2024; 103(39):e39814.

PMID: 39331926 PMC: 11441939. DOI: 10.1097/MD.0000000000039814.


References
1.
Davies N, Holmes M, Davey Smith G . Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. BMJ. 2018; 362:k601. PMC: 6041728. DOI: 10.1136/bmj.k601. View

2.
Grant A, Burgess S . Pleiotropy robust methods for multivariable Mendelian randomization. Stat Med. 2021; 40(26):5813-5830. PMC: 7612169. DOI: 10.1002/sim.9156. View

3.
Strausz S, Havulinna A, Tuomi T, Bachour A, Groop L, Makitie A . Obstructive sleep apnoea and the risk for coronary heart disease and type 2 diabetes: a longitudinal population-based study in Finland. BMJ Open. 2018; 8(10):e022752. PMC: 6194468. DOI: 10.1136/bmjopen-2018-022752. View

4.
Bremer J . Carnitine--metabolism and functions. Physiol Rev. 1983; 63(4):1420-80. DOI: 10.1152/physrev.1983.63.4.1420. View

5.
Manousaki D, Harroud A, Mitchell R, Ross S, Forgetta V, Timpson N . Vitamin D levels and risk of type 1 diabetes: A Mendelian randomization study. PLoS Med. 2021; 18(2):e1003536. PMC: 7906317. DOI: 10.1371/journal.pmed.1003536. View