Right Ventricular Diastolic Dysfunction Worsens Clinical Outcomes in Japanese Patients with Heart Failure

Background: Heart failure (HF) is a rapidly growing public health issue in super aging societies, such as Japan. Right HF is common in older patients. Therefore, the present study investigated the relationship between right ventricular diastolic function and poor clinical outcomes in patients with HF.

Methods: We retrospectively enrolled 387 Japanese HF patients. All data were obtained from our echocardiographic and jugular venous pulse (JVP) databases and medical records. A less-distensible right ventricle (RV) was identified by a deeper 'Y' descent than 'X' descent in the JVP waveform. We defined cardiac events of HF as follows: sudden death, death from HF, emergent infusion of loop diuretics, or hospitalization for deterioration of HF. Comparisons between patients with and without cardiac events and a multivariate analysis of cardiac events were performed.

Results: Eighty-five patients had cardiac events. Left ventricular ejection fraction (LVEF) was lower, average mitral E/e' and the prevalence of a less-distensible RV were higher, and tricuspid annular plane systolic excursion was shorter in patients with than in those without cardiac events (median55vs65, p < 0.001; median15vs11, p < 0.001; 64 %vs27%, p < 0.001; median17vs20, p < 0.001, respectively). In a multivariate Cox proportional hazard model, LVEF and a less-distensible RV were independent risk factors for cardiac events (hazard ratio [HR]:0.983 per 1 % increase, p = 0.048; HR:3.150, p < 0.001, respectively). The event-free rate was the lowest for patients with LVEF < 50 % and a less-distensible RV (p for trend < 0.001).

Conclusions: When right ventricular diastolic function is impaired and irreversible, Japanese patients with HF may become intractable regardless of LVEF.