Repairing the Intestinal Mucosal Barrier of Traditional Chinese Medicine for Ulcerative Colitis: a Review

Overview

Journal Front Pharmacol

Date 2023 Nov 9

PMID 37942490

Authors

Yichen Zong

Jie Meng

Tangyou Mao

Qiang Han

Peng Zhang

Lei Shi

Affiliations

Soon will be listed here.

Abstract

Damage to the intestinal mucosal barrier play an important role in the pathogenesis of ulcerative colitis (UC). Discovering the key regulators and repairing the disturbed barrier are crucial for preventing and treating UC. Traditional Chinese medicine (TCM) has been proved to be effective on treating UC and has exhibited its role in repairing the intestinal mucosal barrier. We summarized the evidence of TCM against UC by protecting and repairing the physical barrier, chemical barrier, immune barrier, and biological barrier. Mechanisms of increasing intestinal epithelial cells, tight junction proteins, and mucins, promoting intestinal stem cell proliferation, restoring the abundance of the intestinal microbiota, and modulating the innate and adaptive immunity in gut, were all involved in. Some upstream proteins and signaling pathways have been elucidated. Based on the existing problems, we suggested future studies paying attention to patients' samples and animal models of UC and TCM syndromes, conducting rescue experiments, exploring more upstream regulators, and adopting new technical methods. We hope this review can provide a theoretical basis and novel ideas for clarifying the mechanisms of TCM against UC via repairing the intestinal mucosal barrier.

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References

Peterson L, Artis D . Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat Rev Immunol. 2014; 14(3):141-53. DOI: 10.1038/nri3608. View

Li Q, Cui Y, Xu B, Wang Y, Lv F, Li Z . Main active components of Jiawei Gegen Qinlian decoction protects against ulcerative colitis under different dietary environments in a gut microbiota-dependent manner. Pharmacol Res. 2021; 170:105694. DOI: 10.1016/j.phrs.2021.105694. View

Gao W, Zhang L, Wang X, Yu L, Wang C, Gong Y . The combination of indirubin and isatin attenuates dextran sodium sulfate induced ulcerative colitis in mice. Biochem Cell Biol. 2018; 96(5):636-645. DOI: 10.1139/bcb-2018-0041. View

Ananthakrishnan A . Epidemiology and risk factors for IBD. Nat Rev Gastroenterol Hepatol. 2015; 12(4):205-17. DOI: 10.1038/nrgastro.2015.34. View

Hao W, Chen Z, Yuan Q, Ma M, Gao C, Zhou Y . Ginger polysaccharides relieve ulcerative colitis via maintaining intestinal barrier integrity and gut microbiota modulation. Int J Biol Macromol. 2022; 219:730-739. DOI: 10.1016/j.ijbiomac.2022.08.032. View

Kang H, Kim C, Seo C, Park Y . The therapeutic applications of antimicrobial peptides (AMPs): a patent review. J Microbiol. 2016; 55(1):1-12. DOI: 10.1007/s12275-017-6452-1. View

Wei Y, Fan Y, Ga Y, Zhang Y, Han J, Hao Z . Shaoyao decoction attenuates DSS-induced ulcerative colitis, macrophage and NLRP3 inflammasome activation through the MKP1/NF-κB pathway. Phytomedicine. 2021; 92:153743. DOI: 10.1016/j.phymed.2021.153743. View

Cosnes J, Gower-Rousseau C, Seksik P, Cortot A . Epidemiology and natural history of inflammatory bowel diseases. Gastroenterology. 2011; 140(6):1785-94. DOI: 10.1053/j.gastro.2011.01.055. View

Luongo D, DArienzo R, Bergamo P, Maurano F, Rossi M . Immunomodulation of gut-associated lymphoid tissue: current perspectives. Int Rev Immunol. 2009; 28(6):446-64. DOI: 10.3109/08830180903236486. View

10.

Fang J, Wang H, Zhou Y, Zhang H, Zhou H, Zhang X . Slimy partners: the mucus barrier and gut microbiome in ulcerative colitis. Exp Mol Med. 2021; 53(5):772-787. PMC: 8178360. DOI: 10.1038/s12276-021-00617-8. View

11.

Ungaro R, Mehandru S, Allen P, Peyrin-Biroulet L, Colombel J . Ulcerative colitis. Lancet. 2016; 389(10080):1756-1770. PMC: 6487890. DOI: 10.1016/S0140-6736(16)32126-2. View

12.

Zheng Y, Liang C, Li Z, Chen J, Chen Z, Jiang Y . Study on the mechanism of Huangqin Decoction on rats with ulcerative colitis of damp-heat type base on mtDNA, TLR4, p-PI3K, p-Akt protein expression and microbiota. J Ethnopharmacol. 2022; 295:115356. DOI: 10.1016/j.jep.2022.115356. View

13.

Zhao J, Wu R, Wei P, Ma Z, Pei H, Hu J . Ethanol extract of Piper wallichii ameliorates DSS-induced ulcerative colitis in mice: Involvement of TLR4/NF-κB/COX-2 signaling pathway. J Ethnopharmacol. 2023; 308:116293. DOI: 10.1016/j.jep.2023.116293. View

14.

Zhao Y, Luan H, Gao H, Wu X, Zhang Y, Li R . Gegen Qinlian decoction maintains colonic mucosal homeostasis in acute/chronic ulcerative colitis via bidirectionally modulating dysregulated Notch signaling. Phytomedicine. 2020; 68:153182. DOI: 10.1016/j.phymed.2020.153182. View

15.

Hua Y, Jia Y, Zhang X, Yuan Z, Ji P, Hu J . Baitouweng Tang ameliorates DSS-induced ulcerative colitis through the regulation of the gut microbiota and bile acids via pathways involving FXR and TGR5. Biomed Pharmacother. 2021; 137:111320. DOI: 10.1016/j.biopha.2021.111320. View

16.

Yan S, Wang P, Wei H, Jia R, Zhen M, Li Q . Treatment of ulcerative colitis with Wu-Mei-Wan by inhibiting intestinal inflammatory response and repairing damaged intestinal mucosa. Phytomedicine. 2022; 105:154362. DOI: 10.1016/j.phymed.2022.154362. View

17.

Li H, Fan C, Lu H, Feng C, He P, Yang X . Protective role of berberine on ulcerative colitis through modulating enteric glial cells-intestinal epithelial cells-immune cells interactions. Acta Pharm Sin B. 2020; 10(3):447-461. PMC: 7049614. DOI: 10.1016/j.apsb.2019.08.006. View

18.

Turpin W, Lee S, Raygoza Garay J, Madsen K, Meddings J, Bedrani L . Increased Intestinal Permeability Is Associated With Later Development of Crohn's Disease. Gastroenterology. 2020; 159(6):2092-2100.e5. DOI: 10.1053/j.gastro.2020.08.005. View

19.

Harbord M, Eliakim R, Bettenworth D, Karmiris K, Katsanos K, Kopylov U . Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 2: Current Management. J Crohns Colitis. 2017; 11(7):769-784. DOI: 10.1093/ecco-jcc/jjx009. View

20.

Ren Z, Guo C, Yu S, Zhu L, Wang Y, Hu H . Progress in Mycotoxins Affecting Intestinal Mucosal Barrier Function. Int J Mol Sci. 2019; 20(11). PMC: 6600655. DOI: 10.3390/ijms20112777. View