Antimycobacterial Precatorin A Flavonoid Displays Antibiofilm Activity Against BCG

Overview

Journal ACS Omega

Publisher American Chemical Society

Specialty Chemistry

Date 2023 Nov 6

PMID 37929145

Authors

Esmeralda Ivonne Nino-Padilla

Clara Espitia

Carlos Velazquez

Efrain Alday

Erika Silva-Campa

Alexel Burgara-Estrella

Jose Antonio Enciso-Moreno

Olivia Valenzuela

Humberto Astiazaran-Garcia

Adriana Garibay-Escobar

Affiliations

Soon will be listed here.

Abstract

The aim of this study was to evaluate the potential antibiofilm activity of () compounds over BCG ( BCG) as a model for (). We evaluated the antibiofilm activity as the ability to both inhibit biofilm formation and disrupt preformed biofilms (bactericidal) of compounds, which have been previously described as being antimycobacterials against . BCG developed air-liquid interface biofilms with surface attachment ability and drug tolerance. Of the extracts and compounds that were tested, precatorin A (PreA) displayed the best biofilm inhibitory activity, as evaluated by biofilm biomass quantification, viable cell count, and confocal and atomic force microscopy procedures. Furthermore, its combination with isoniazid at subinhibitory concentrations inhibited BCG biofilm formation. Nonetheless, neither PreA nor the extract showed bactericidal effects. PreA is the compound responsible for biofilm inhibitory activity against BCG.

Citing Articles

Ajoene: a natural compound with enhanced antimycobacterial and antibiofilm properties mediated by efflux pump modulation and ROS generation against M. Smegmatis.

Sarangi A, Das B, Pahuja I, Ojha S, Singh V, Giri S Arch Microbiol. 2024; 206(12):453.

PMID: 39487375 DOI: 10.1007/s00203-024-04189-9.

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