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Comparison of Susceptibility of Gentamicin-resistant and -susceptible "Acinetobacter Anitratus" to 15 Alternative Antibiotics

Overview
Journal Antimicrob Agents Chemother
Publisher American Society for Microbiology
Specialty Pharmacology
Date 1986 Oct 1
PMID 3789698
Citations 3
Authors
H G Stiver
K H Bartlett
A W Chow
Affiliations
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Abstract

Fifty-four clinical isolates of "Acinetobacter anitratus" separated cleanly into gentamicin-susceptible (16 strains) and gentamicin-resistant (38 strains) subpopulations. When tested with a 10(4)-CFU inoculum, gentamicin resistance was associated with a greater than fourfold increase in the MICs of norfloxacin, ciprofloxacin, A-56620, tobramycin, and amikacin for 50% of the strains. Antimicrobial agents with MICs for 90% of gentamicin-resistant strains in the susceptible range were ciprofloxacin, A-56619, A-56620, imipenem, SCH-34343, ceftazidime, aztreonam, carbenicillin, ticarcillin, and piperacillin. These agents may be useful alternative drugs for treating infections caused by aminoglycoside-susceptible and -resistant "A. anitratus."

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Fluoroquinolone antimicrobial agents.

Wolfson J, Hooper D Clin Microbiol Rev. 1989; 2(4):378-424.

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Cross resistance to ciprofloxacin and other antimicrobial agents among clinical isolates of Acinetobacter calcoaceticus biovar anitratus.

Shalit I, Dan M, Gutman R, Gorea A, Berger S Antimicrob Agents Chemother. 1990; 34(3):494-5.

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