Oncomeric Profiles of MicroRNAs As New Therapeutic Targets for Treatment of Ewing's Sarcoma: A Composite Review

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2023 Oct 28

PMID 37895198

Authors

Mubashir Hassan

Saba Shahzadi

Amal Malik

Salah Ud Din

Muhammad Yasir

Wanjoo Chun

Andrzej Kloczkowski

Affiliations

Soon will be listed here.

Abstract

Ewing's sarcoma is a rare type of cancer that forms in bones and soft tissues in the body, affecting mostly children and young adults. Current treatments for ES are limited to chemotherapy and/or radiation, followed by surgery. Recently, microRNAs have shown favourable results as latent diagnostic and prognostic biomarkers in various cancers. Furthermore, microRNAs have shown to be a good therapeutic agent due to their involvement in the dysregulation of various molecular pathways linked to tumour progression, invasion, angiogenesis, and metastasis. In this review, comprehensive data mining was employed to explore various microRNAs that might have therapeutic potential as target molecules in the treatment of ES.

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