MicroRNAs As Novel Regulators of Stem Cell Pluripotency and Somatic Cell Reprogramming

Overview

Journal Bioessays

Publisher Wiley

Specialties Biology
Cell Biology
Molecular Biology

Date 2012 Jun 8

PMID 22674461

Citations 38

Authors

Meng Amy Li

Lin He

Affiliations

Soon will be listed here.

Abstract

Emerging evidence suggests that microRNA (miRNA)-mediated post-transcriptional gene regulation plays an essential role in modulating embryonic stem (ES) cell pluripotency maintenance, differentiation, and reprogramming of somatic cells to an ES cell-like state. Investigations from ES cell-enriched miRNAs, such as mouse miR-290 cluster and human miR-302 cluster, and ES cell-depleted miRNAs such as let-7 family miRNAs, revealed a common theme that miRNAs target diverse cellular processes including cell cycle regulators, signaling pathway effectors, transcription factors, and epigenetic modifiers and shape their protein output. The combinatorial effects downstream of miRNA action allow miRNAs to modulate cell-fate decisions effectively. Furthermore, the transcription and biogenesis of miRNAs are also tightly regulated. Thus, elucidating the interplay between miRNAs and other modes of gene regulation will shed new light on the biology of pluripotent stem cells and somatic cell reprogramming.

Citing Articles

Harnessing the power of miRNAs for precision diagnosis and treatment of male infertility.

Doghish A, Elsakka E, Ahmed Mohamed Moustafa H, Ashraf A, Mageed S, Mohammed O Naunyn Schmiedebergs Arch Pharmacol. 2024; .

PMID: 39535597 DOI: 10.1007/s00210-024-03594-7.

MiR-290 Family Maintains Pluripotency and Self-Renewal by Regulating MAPK Signaling Pathway in Intermediate Pluripotent Stem Cells.

Liu Y, Li X, Ma X, Du Q, Wang J, Yu H Int J Mol Sci. 2024; 25(5).

PMID: 38473927 PMC: 10931995. DOI: 10.3390/ijms25052681.

Oncomeric Profiles of microRNAs as New Therapeutic Targets for Treatment of Ewing's Sarcoma: A Composite Review.

Hassan M, Shahzadi S, Malik A, Din S, Yasir M, Chun W Genes (Basel). 2023; 14(10).

PMID: 37895198 PMC: 10606885. DOI: 10.3390/genes14101849.

Integration of a multi-omics stem cell differentiation dataset using a dynamical model.

van den Berg P, Berenger-Currias N, Budnik B, Slavov N, Semrau S PLoS Genet. 2023; 19(5):e1010744.

PMID: 37167320 PMC: 10204997. DOI: 10.1371/journal.pgen.1010744.

Exosome-guided direct reprogramming of tumor-associated macrophages from protumorigenic to antitumorigenic to fight cancer.

Kim H, Park H, Chang H, Back J, Lee S, Park Y Bioact Mater. 2023; 25:527-540.

PMID: 37056267 PMC: 10087080. DOI: 10.1016/j.bioactmat.2022.07.021.

References

Li R, Liang J, Ni S, Zhou T, Qing X, Li H . A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell. 2010; 7(1):51-63. DOI: 10.1016/j.stem.2010.04.014. View

Niwa H, Ogawa K, Shimosato D, Adachi K . A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells. Nature. 2009; 460(7251):118-22. DOI: 10.1038/nature08113. View

Choi Y, Lin C, Ho J, He X, Okada N, Bu P . miR-34 miRNAs provide a barrier for somatic cell reprogramming. Nat Cell Biol. 2011; 13(11):1353-60. PMC: 3541684. DOI: 10.1038/ncb2366. View

Ambros V, Horvitz H . Heterochronic mutants of the nematode Caenorhabditis elegans. Science. 1984; 226(4673):409-16. DOI: 10.1126/science.6494891. View

Mayr C, Bartel D . Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells. Cell. 2009; 138(4):673-84. PMC: 2819821. DOI: 10.1016/j.cell.2009.06.016. View

Wang Y, Medvid R, Melton C, Jaenisch R, Blelloch R . DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat Genet. 2007; 39(3):380-5. PMC: 3008549. DOI: 10.1038/ng1969. View

Brons I, Smithers L, Trotter M, Rugg-Gunn P, Sun B, Chuva de Sousa Lopes S . Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature. 2007; 448(7150):191-5. DOI: 10.1038/nature05950. View

Thomson J, Newman M, Parker J, Morin-Kensicki E, Wright T, Hammond S . Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev. 2006; 20(16):2202-7. PMC: 1553203. DOI: 10.1101/gad.1444406. View

Viswanathan S, Daley G, Gregory R . Selective blockade of microRNA processing by Lin28. Science. 2008; 320(5872):97-100. PMC: 3368499. DOI: 10.1126/science.1154040. View

10.

Carey B, Markoulaki S, Hanna J, Faddah D, Buganim Y, Kim J . Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells. Cell Stem Cell. 2011; 9(6):588-98. DOI: 10.1016/j.stem.2011.11.003. View

11.

Kim V, Han J, Siomi M . Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol. 2009; 10(2):126-39. DOI: 10.1038/nrm2632. View

12.

Jaenisch R, Young R . Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell. 2008; 132(4):567-82. PMC: 4142810. DOI: 10.1016/j.cell.2008.01.015. View

13.

Subramanyam D, Lamouille S, Judson R, Liu J, Bucay N, Derynck R . Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nat Biotechnol. 2011; 29(5):443-8. PMC: 3685579. DOI: 10.1038/nbt.1862. View

14.

Theunissen T, van Oosten A, Castelo-Branco G, Hall J, Smith A, Silva J . Nanog overcomes reprogramming barriers and induces pluripotency in minimal conditions. Curr Biol. 2011; 21(1):65-71. PMC: 3025321. DOI: 10.1016/j.cub.2010.11.074. View

15.

Samavarchi-Tehrani P, Golipour A, David L, Sung H, Beyer T, Datti A . Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell. 2010; 7(1):64-77. DOI: 10.1016/j.stem.2010.04.015. View

16.

Rybak A, Fuchs H, Smirnova L, Brandt C, Pohl E, Nitsch R . A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nat Cell Biol. 2008; 10(8):987-93. DOI: 10.1038/ncb1759. View

17.

Takahashi K, Yamanaka S . Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006; 126(4):663-76. DOI: 10.1016/j.cell.2006.07.024. View

18.

Rosa A, Brivanlou A . A regulatory circuitry comprised of miR-302 and the transcription factors OCT4 and NR2F2 regulates human embryonic stem cell differentiation. EMBO J. 2010; 30(2):237-48. PMC: 3025464. DOI: 10.1038/emboj.2010.319. View

19.

Stadtfeld M, Apostolou E, Akutsu H, Fukuda A, Follett P, Natesan S . Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature. 2010; 465(7295):175-81. PMC: 3987905. DOI: 10.1038/nature09017. View

20.

Wang Y, Baskerville S, Shenoy A, Babiarz J, Baehner L, Blelloch R . Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation. Nat Genet. 2008; 40(12):1478-83. PMC: 2630798. DOI: 10.1038/ng.250. View