Na Binding and Transport: Insights from Light-Driven Na-Pumping Rhodopsin

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2023 Oct 28

PMID 37894614

Authors

Qifan Yang

Deliang Chen

Affiliations

Soon will be listed here.

Abstract

Na plays a vital role in numerous physiological processes across humans and animals, necessitating a comprehensive understanding of Na transmembrane transport. Among the various Na pumps and channels, light-driven Na-pumping rhodopsin (NaR) has emerged as a noteworthy model in this field. This review offers a concise overview of the structural and functional studies conducted on NaR, encompassing ground/intermediate-state structures and photocycle kinetics. The primary focus lies in addressing key inquiries: (1) unraveling the translocation pathway of Na; (2) examining the role of structural changes within the photocycle, particularly in the O state, in facilitating Na transport; and (3) investigating the timing of Na uptake/release. By delving into these unresolved issues and existing debates, this review aims to shed light on the future direction of Na pump research.

Citing Articles

Light Control in Microbial Systems.

Elahi Y, Baker M Int J Mol Sci. 2024; 25(7).

PMID: 38612810 PMC: 11011852. DOI: 10.3390/ijms25074001.

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