A Population-Based Outcome-Wide Association Study of the Comorbidities and Sequelae Following COVID-19 Infection

Overview

Journal J Epidemiol Glob Health

Publisher Springer

Date 2023 Oct 27

PMID 37889436

Authors

Yuyang Zhang

Junhong Li

Lan Feng

Yaxin Luo

Wendu Pang

Ke Qiu

Minzi Mao

Yao Song

Danni Cheng

Yufang Rao

Xinyi Wang

Yao Hu

Zhiye Ying

Xiaobin Pu

Shuyan Lin

Shaohui Huang

Geoffrey Liu

Wei Zhang

Wei Xu

Yu Zhao

Jianjun Ren

Affiliations

Soon will be listed here.

Abstract

Background: Immense attention has been given to the outcome of COVID-19 infection. However, comprehensive studies based on large populational cohort with long-term follow-up are still lacking. This study aimed to investigate the risk of various short-term comorbidities (within one month) and long-term sequelae (above one month) after COVID-19 infection.

Methods: In this large prospective cohort study with 14 months follow-up information based on UK biobank, we included 16,776 COVID-19-positive participants and 58,281 COVID-19-negative participants matched for comparison. The risk of each comorbidity and sequela was evaluated by multivariable logistic regression analysis and presented as hazard ratio (HR) and 95% confidence interval (95% CI).

Results: COVID-19-positive individuals had a higher risk of 47 types of comorbidities within one month following COVID-19 infection, especially those who were older, male, overweight/obese, ever-smoked, with more pre-existing comorbidities and hospitalized. About 70.37% of COVID-19 patients with comorbidities had more than one co-occurring comorbidities. Additionally, only 6 high-risk sequelae were observed after one month of COVID-19 infection, and the incidence was relatively low (< 1%).

Conclusion: In addition to long-term sequelae following COVID-19 infection, plenty of comorbidities were observed, especially in patients with older age, male gender, overweight/obese, more pre-existing comorbidities and severe COVID-19, indicating that more attention should be given to these susceptible persons within this period.

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