Lymphangiogenic Responses of Lymphatic Endothelial Cells to Steady Direct-current Electric Fields

Overview

Journal Cell Adh Migr

Specialty Cell Biology

Date 2023 Oct 27

PMID 37889090

Authors

Linbo Guan

Ping Fan

Yufeng Wang

Xinghui Liu

Rui Liu

Wandi Ma

Huai Bai

Affiliations

Soon will be listed here.

Abstract

Lymphangiogenesis plays pivotal roles in diverse physiological and pathological conditions. Steady direct-current electric fields (DC EFs) induce vascular endothelial behaviors related to angiogenesis have been observed. This study investigated the effects of DC EFs on the lymphangiogenic response of lymphatic endothelial cells (LECs). We demonstrated that EFs stimulation induced directional migration, reorientation, and elongation of human LECs in culture. These lymphangiogenic responses required VEGF receptor 3 (VEGFR-3) activation and were mediated through the PI3K-Akt, Erk1/2, and p38 MAPK signaling pathways in relation to the reorganization of the actin cytoskeleton. Our results indicate that endogenous EFs may play a role in lymphangiogenesis in vivo, and VEGFR-3 signaling activation may be involved in the cellular function of LECs driven by EFs.

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