The Endocannabinoid N-arachidonoyl Dopamine is Critical for Hyperalgesia Induced by Chronic Sleep Disruption

Overview

Journal Nat Commun

Specialty Biology

Date 2023 Oct 25

PMID 37880241

Authors

Weihua Ding

Liuyue Yang

Eleanor Shi

Bowon Kim

Sarah Low

Kun Hu

Lei Gao

Ping Chen

Wei Ding

David Borsook

Andrew Luo

Jee Hyun Choi

Changning Wang

Oluwaseun Akeju

Jun Yang

Chongzhao Ran

Kristin L Schreiber

Jianren Mao

Qian Chen

Guoping Feng

Shiqian Shen

Affiliations

Soon will be listed here.

Abstract

Chronic pain is highly prevalent and is linked to a broad range of comorbidities, including sleep disorders. Epidemiological and clinical evidence suggests that chronic sleep disruption (CSD) leads to heightened pain sensitivity, referred to as CSD-induced hyperalgesia. However, the underlying mechanisms are unclear. The thalamic reticular nucleus (TRN) has unique integrative functions in sensory processing, attention/arousal and sleep spindle generation. We report that the TRN played an important role in CSD-induced hyperalgesia in mice, through its projections to the ventroposterior region of the thalamus. Metabolomics revealed that the level of N-arachidonoyl dopamine (NADA), an endocannabinoid, was decreased in the TRN after CSD. Using a recently developed CB1 receptor (cannabinoid receptor 1) activity sensor with spatiotemporal resolution, CB1 receptor activity in the TRN was found to be decreased after CSD. Moreover, CSD-induced hyperalgesia was attenuated by local NADA administration to the TRN. Taken together, these results suggest that TRN NADA signaling is critical for CSD-induced hyperalgesia.

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