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Alterations in Adipose Tissue Distribution, Cell Morphology, and Function Mark Primary Insulin Hypersecretion in Youth With Obesity

Overview
Journal Diabetes
Specialty Endocrinology
Date 2023 Oct 23
PMID 37870826
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Abstract

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References
1.
Erion K, Corkey B . Hyperinsulinemia: a Cause of Obesity?. Curr Obes Rep. 2017; 6(2):178-186. PMC: 5487935. DOI: 10.1007/s13679-017-0261-z. View

2.
Lonnqvist F, Nordfors L, Jansson M, Thorne A, Schalling M, Arner P . Leptin secretion from adipose tissue in women. Relationship to plasma levels and gene expression. J Clin Invest. 1997; 99(10):2398-404. PMC: 508079. DOI: 10.1172/JCI119422. View

3.
Pories W, Dohm G . Diabetes: have we got it all wrong? Hyperinsulinism as the culprit: surgery provides the evidence. Diabetes Care. 2012; 35(12):2438-42. PMC: 3507594. DOI: 10.2337/dc12-0684. View

4.
Hoffstedt J, Arner E, Wahrenberg H, Andersson D, Qvisth V, Lofgren P . Regional impact of adipose tissue morphology on the metabolic profile in morbid obesity. Diabetologia. 2010; 53(12):2496-503. DOI: 10.1007/s00125-010-1889-3. View

5.
Fryk E, Olausson J, Mossberg K, Strindberg L, Schmelz M, Brogren H . Hyperinsulinemia and insulin resistance in the obese may develop as part of a homeostatic response to elevated free fatty acids: A mechanistic case-control and a population-based cohort study. EBioMedicine. 2021; 65:103264. PMC: 7992078. DOI: 10.1016/j.ebiom.2021.103264. View