Romy Kursawe
Overview
Explore the profile of Romy Kursawe including associated specialties, affiliations and a list of published articles.
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Articles
41
Citations
2121
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0
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Recent Articles
1.
Bandesh K, Motakis E, Nargund S, Kursawe R, Selvam V, Bhuiyan R, et al.
bioRxiv
. 2025 Feb;
PMID: 39896672
Pancreatic islets maintain glucose homeostasis through coordinated action of their constituent endocrine and affiliate cell types and are central to type 2 diabetes (T2D) genetics and pathophysiology. Our understanding of...
2.
Sokolowski E, Kursawe R, Selvam V, Bhuiyan R, Thibodeau A, Zhao C, et al.
Cell Metab
. 2024 Oct;
36(11):2468-2488.e7.
PMID: 39383866
Endoplasmic reticulum (ER) and inflammatory stress responses contribute to islet dysfunction in type 2 diabetes (T2D). Comprehensive genomic understanding of these human islet stress responses and whether T2D-associated genetic variants...
3.
Li J, Zhu J, Deng Y, Reck E, Walker E, Sidarala V, et al.
bioRxiv
. 2024 Jun;
PMID: 38895283
Proteotoxicity is a contributor to the development of type 2 diabetes (T2D), but it is unknown whether protein misfolding in T2D is generalized or has special features. Here, we report...
4.
Trico D, Chiriaco M, Nouws J, Vash-Margita A, Kursawe R, Tarabra E, et al.
Diabetes
. 2023 Oct;
73(6):941-952.
PMID: 37870826
Article Highlights:
5.
Tyler A, Spruce C, Kursawe R, Haber A, Ball R, Pitman W, et al.
Genome Res
. 2023 May;
33(6):857-871.
PMID: 37217254
The Diversity Outbred (DO) mice and their inbred founders are widely used models of human disease. However, although the genetic diversity of these mice has been well documented, their epigenetic...
6.
Khetan S, Kales S, Kursawe R, Jillette A, Ulirsch J, Reilly S, et al.
Nat Commun
. 2021 Sep;
12(1):5242.
PMID: 34475398
Genome-wide association studies (GWAS) have linked single nucleotide polymorphisms (SNPs) at >250 loci in the human genome to type 2 diabetes (T2D) risk. For each locus, identifying the functional variant(s)...
7.
Thibodeau A, Eroglu A, McGinnis C, Lawlor N, Nehar-Belaid D, Kursawe R, et al.
Genome Biol
. 2021 Sep;
22(1):252.
PMID: 34465366
Detecting multiplets in single nucleus (sn)ATAC-seq data is challenging due to data sparsity and limited dynamic range. AMULET (ATAC-seq MULtiplet Estimation Tool) enumerates regions with greater than two uniquely aligned...
8.
Rui J, Deng S, Perdigoto A, Ponath G, Kursawe R, Lawlor N, et al.
Nat Commun
. 2021 Aug;
12(1):5074.
PMID: 34417463
β cells may participate and contribute to their own demise during Type 1 diabetes (T1D). Here we report a role of their expression of Tet2 in regulating immune killing. Tet2...
9.
Nouws J, Fitch M, Mata M, Santoro N, Galuppo B, Kursawe R, et al.
Diabetes
. 2019 Apr;
68(6):1168-1177.
PMID: 30936147
Patterns of abdominal fat distribution (for example, a high vs. low visceral adipose tissue [VAT]/[VAT + subcutaneous adipose tissue (SAT)] ratio), independent of obesity, during adolescence carry a high risk...
10.
Lawlor N, Marquez E, Orchard P, Narisu N, Shamim M, Thibodeau A, et al.
Cell Rep
. 2019 Jan;
26(3):788-801.e6.
PMID: 30650367
EndoC-βH1 is emerging as a critical human β cell model to study the genetic and environmental etiologies of β cell (dys)function and diabetes. Comprehensive knowledge of its molecular landscape is...