Preincubation of Homogenates from Rat Brain Thalamus and Striatum Affects the Rate of [3H]GABA Uptake

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 1986 Oct 1

PMID 3785537

Authors

M V Rapallino

A Cupello

Affiliations

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Abstract

The effect of preincubation of brain homogenates on the subsequent uptake of [3H]GABA was studied in rat thalamus and corpus striatum. The results show that in both brain regions preincubation causes a decrease in the initial rate of [3H]GABA influx, the phenomenon being most evident in the thalamus.

References

Martin D . Kinetics of the sodium-dependent transport of gamma-aminobutyric acid by synaptosomes. J Neurochem. 1973; 21(2):345-56. DOI: 10.1111/j.1471-4159.1973.tb04255.x. View

Levi G, Raiteri M . Detectability of high and low affinity uptake systems for GABA and glutamate in rat brain slices and synaptosomes. Life Sci I. 1973; 12(2):81-8. DOI: 10.1016/0024-3205(73)90064-7. View

Pastuszko A, Wilson D, Erecinska M . Net uptake of gamma-aminobutyric acid by a high-affinity system of rat brain synaptosomes. Proc Natl Acad Sci U S A. 1981; 78(2):1242-4. PMC: 319984. DOI: 10.1073/pnas.78.2.1242. View

Levi G, Raiteri M . Modulation of gamma-aminobutyric acid transport in nerve endings: role of extracellular gamma-aminobutyric acid and of cationic fluxes. Proc Natl Acad Sci U S A. 1978; 75(6):2981-5. PMC: 392691. DOI: 10.1073/pnas.75.6.2981. View

Simon J, Martin D, Kroll M . Sodium-dependent efflux and exchange of GABA in synaptosomes. J Neurochem. 1974; 23(5):981-91. DOI: 10.1111/j.1471-4159.1974.tb10750.x. View

Iversen L, Bloom F . Studies of the uptake of 3 H-gaba and ( 3 H)glycine in slices and homogenates of rat brain and spinal cord by electron microscopic autoradiography. Brain Res. 1972; 41(1):131-43. DOI: 10.1016/0006-8993(72)90621-x. View

Sellstrom A, Venema R, Henn F . Functional assessment of GABA uptake or exchange by synaptosomal fractions. Nature. 1976; 264(5587):652-3. DOI: 10.1038/264652a0. View

Nomura Y, Okuma Y, Segawa T, Schmidt-Glenewinkel T, Giacobini E . Comparison of synaptosomal and glial uptake of pipecolic acid and GABA in rat brain. Neurochem Res. 1981; 6(4):391-400. DOI: 10.1007/BF00963854. View

Fahn S, Cote L . Regional distribution of gamma-aminobutyric acid (GABA) in brain of the rhesus monkey. J Neurochem. 1968; 15(3):209-13. DOI: 10.1111/j.1471-4159.1968.tb06198.x. View

10.

Iversen L, Johnston G . GABA uptake in rat central nervous system: comparison of uptake in slices and homogenates and the effects of some inhibitors. J Neurochem. 1971; 18(10):1939-50. DOI: 10.1111/j.1471-4159.1971.tb09600.x. View

11.

Chweh A, Leslie S . Phosphatidylserine enhancement of [3H]gamma-aminobutyric acid uptake by rat whole brain synaptosomes. J Neurochem. 1982; 38(3):691-5. DOI: 10.1111/j.1471-4159.1982.tb08687.x. View

12.

Peterson N, Raghupathy E . Characteristics of amino acid accumulation by synaptosomal particles isolated from rat brain. J Neurochem. 1972; 19(6):1423-38. DOI: 10.1111/j.1471-4159.1972.tb05086.x. View

13.

Glowinski J, Iversen L . Regional studies of catecholamines in the rat brain. I. The disposition of [3H]norepinephrine, [3H]dopamine and [3H]dopa in various regions of the brain. J Neurochem. 1966; 13(8):655-69. DOI: 10.1111/j.1471-4159.1966.tb09873.x. View

14.

Hitzemann R, Loh H . A comparison of GABA and beta-alanine transport and GABA membrane binding in the rat brain. J Neurochem. 1978; 30(2):471-7. DOI: 10.1111/j.1471-4159.1978.tb06552.x. View

15.

Henke H, Schenker T, Cuenod M . Uptake of neurotransmitter candidates by pigeon optic tectum. J Neurochem. 1976; 26(1):125-30. View

16.

Enna S, Kuhar M, Snyder S . Regional distribution of postsynaptic receptor binding for gamma-aminobutyric acid (GABA) in monkey brain. Brain Res. 1975; 93(1):168-74. DOI: 10.1016/0006-8993(75)90297-8. View

17.

Chan P, Kerlan R, Fishman R . Reductions of gamma-aminobutyric acid and glutamate uptake and (Na+ + K+)-ATPase activity in brain slices and synaptosomes by arachidonic acid. J Neurochem. 1983; 40(2):309-16. DOI: 10.1111/j.1471-4159.1983.tb11284.x. View