Recurrent DNMT3B Rearrangements Are Associated with Unfavorable Outcome in Dicentric (9;20)-positive Pediatric BCP-ALL

Overview

Journal Leukemia

Specialties Hematology
Oncology

Date 2023 Oct 16

PMID 37845283

Authors

Zeljko Antic

Alena van Bommel

Konstantin Riege

Jana Lentes

Charlotte Schroder

Julia Alten

Cornelia Eckert

Lara Fuhrmann

Doris Steinemann

Lennart Lenk

Denis M Schewe

Martin Zimmermann

Martin Schrappe

Brigitte Schlegelberger

Gunnar Cario

Steve Hoffmann

Anke K Bergmann

Affiliations

Soon will be listed here.

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References

Clark R, Byatt S, Bennett C, Brama M, Martineau M, Moorman A . Monosomy 20 as a pointer to dicentric (9;20) in acute lymphoblastic leukemia. Leukemia. 2000; 14(2):241-6. DOI: 10.1038/sj.leu.2401654. View

Forestier E, Gauffin F, Andersen M, Autio K, Borgstrom G, Golovleva I . Clinical and cytogenetic features of pediatric dic(9;20)(p13.2;q11.2)-positive B-cell precursor acute lymphoblastic leukemias: a Nordic series of 24 cases and review of the literature. Genes Chromosomes Cancer. 2007; 47(2):149-58. DOI: 10.1002/gcc.20517. View

Zachariadis V, Gauffin F, Kuchinskaya E, Heyman M, Schoumans J, Blennow E . The frequency and prognostic impact of dic(9;20)(p13.2;q11.2) in childhood B-cell precursor acute lymphoblastic leukemia: results from the NOPHO ALL-2000 trial. Leukemia. 2011; 25(4):622-8. DOI: 10.1038/leu.2010.318. View

An Q, Wright S, Moorman A, Parker H, Griffiths M, Ross F . Heterogeneous breakpoints in patients with acute lymphoblastic leukemia and the dic(9;20)(p11-13;q11) show recurrent involvement of genes at 20q11.21. Haematologica. 2009; 94(8):1164-9. PMC: 2719040. DOI: 10.3324/haematol.2008.002808. View

Schoumans J, Johansson B, Corcoran M, Kuchinskaya E, Golovleva I, Grander D . Characterisation of dic(9;20)(p11-13;q11) in childhood B-cell precursor acute lymphoblastic leukaemia by tiling resolution array-based comparative genomic hybridisation reveals clustered breakpoints at 9p13.2 and 20q11.2. Br J Haematol. 2006; 135(4):492-9. DOI: 10.1111/j.1365-2141.2006.06328.x. View

Zachariadis V, Schoumans J, Barbany G, Heyman M, Forestier E, Johansson B . Homozygous deletions of CDKN2A are present in all dic(9;20)(p13·2;q11·2)-positive B-cell precursor acute lymphoblastic leukaemias and may be important for leukaemic transformation. Br J Haematol. 2012; 159(4):488-91. DOI: 10.1111/bjh.12051. View

Pichler H, Moricke A, Mann G, Teigler-Schlegel A, Niggli F, Nebral K . Prognostic relevance of dic(9;20)(p11;q13) in childhood B-cell precursor acute lymphoblastic leukaemia treated with Berlin-Frankfurt-Münster (BFM) protocols containing an intensive induction and post-induction consolidation therapy. Br J Haematol. 2010; 149(1):93-100. DOI: 10.1111/j.1365-2141.2009.08059.x. View

Letouzey M, Penther D, Roche-Lestienne C, Nelken B, Devoldere C, Vannier J . Detection of dicentric chromosome (9;20) in paediatric B-cell acute lymphoblastic leukaemia: prognostic significance. Ann Hematol. 2014; 94(2):187-93. DOI: 10.1007/s00277-014-2204-z. View

Stanulla M, Dagdan E, Zaliova M, Moricke A, Palmi C, Cazzaniga G . IKZF1 Defines a New Minimal Residual Disease-Dependent Very-Poor Prognostic Profile in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia. J Clin Oncol. 2018; 36(12):1240-1249. DOI: 10.1200/JCO.2017.74.3617. View

10.

Gagliardi M, Strazzullo M, Matarazzo M . DNMT3B Functions: Novel Insights From Human Disease. Front Cell Dev Biol. 2018; 6:140. PMC: 6204409. DOI: 10.3389/fcell.2018.00140. View

11.

Liang G, Chan M, Tomigahara Y, Tsai Y, Gonzales F, Li E . Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Mol Cell Biol. 2002; 22(2):480-91. PMC: 139739. DOI: 10.1128/MCB.22.2.480-491.2002. View

12.

Chen T, Ueda Y, Dodge J, Wang Z, Li E . Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b. Mol Cell Biol. 2003; 23(16):5594-605. PMC: 166327. DOI: 10.1128/MCB.23.16.5594-5605.2003. View

13.

Pastore A, Gaiti F, Lu S, Brand R, Kulm S, Chaligne R . Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL. Nat Commun. 2019; 10(1):1874. PMC: 6478836. DOI: 10.1038/s41467-019-09645-5. View

14.

Beekman R, Chapaprieta V, Russinol N, Vilarrasa-Blasi R, Verdaguer-Dot N, Martens J . The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemia. Nat Med. 2018; 24(6):868-880. PMC: 6363101. DOI: 10.1038/s41591-018-0028-4. View

15.

Ziegler S, Marth J, Lewis D, Perlmutter R . Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin. Mol Cell Biol. 1987; 7(6):2276-85. PMC: 365352. DOI: 10.1128/mcb.7.6.2276-2285.1987. View