Forecasting the Future of Antiphospholipid Syndrome: Prospects and Challenges
Overview
Overview
Authors
Authors
Affiliations
Affiliations
Soon will be listed here.
Abstract
Antiphospholipid syndrome (APS) is an autoimmune condition affecting young patients, primarily women, negatively impacting their quality of life. APS is under-recognized and underdiagnosed and can have devastating results if untreated, mainly due to uncontrolled thrombosis. Research in the past decades has led to several breakthroughs with important implications for clinical practice. Here, we summarize the state of APS diagnosis, treatment, pathophysiology, and research directions that hold promise for advancing diagnosis and treatment.
References
1.
Kumar S, Chinnaraj M, Planer W, Zuo X, Macor P, Tedesco F
. An allosteric redox switch in domain V of β-glycoprotein I controls membrane binding and anti-domain I autoantibody recognition. J Biol Chem. 2021; 297(2):100890.
PMC: 8326733.
DOI: 10.1016/j.jbc.2021.100890.
View
2.
Garcia D, Erkan D
. Diagnosis and Management of the Antiphospholipid Syndrome. N Engl J Med. 2018; 378(21):2010-2021.
DOI: 10.1056/NEJMra1705454.
View
3.
Cervera R, Piette J, Font J, Khamashta M, Shoenfeld Y, Camps M
. Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients. Arthritis Rheum. 2002; 46(4):1019-27.
DOI: 10.1002/art.10187.
View
4.
Schulz A, Herrmann E, Ott O, Lindhoff-Last E
. Thromboembolic Antiphospholipid Syndrome (APS): Efficacy and Safety of Different Anticoagulants-Results of the APSantiCO Registry. J Clin Med. 2022; 11(16).
PMC: 9409774.
DOI: 10.3390/jcm11164845.
View
5.
van den Hoogen L, Bisoendial R
. B-Cells and BAFF in Primary Antiphospholipid Syndrome, Targets for Therapy?. J Clin Med. 2023; 12(1).
PMC: 9821657.
DOI: 10.3390/jcm12010018.
View