Research Progress of NF-κB Signaling Pathway and Thrombosis

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2023 Oct 16

PMID 37841272

Authors

Zilong Wang

Chucun Fang

Mengting Yao

Dongwen Wu

Maga Chen

Tianting Guo

Jianwen Mo

Affiliations

Soon will be listed here.

Abstract

Venous thromboembolism is a very common and costly health problem. Deep-vein thrombosis (DVT) can cause permanent damage to the venous system and lead to swelling, ulceration, gangrene, and other symptoms in the affected limb. In addition, more than half of the embolus of pulmonary embolism comes from venous thrombosis, which is the most serious cause of death, second only to ischemic heart disease and stroke patients. It can be seen that deep-vein thrombosis has become a serious disease affecting human health. In recent years, with the deepening of research, inflammatory response is considered to be an important pathway to trigger venous thromboembolism, in which the transcription factor NF-κB is the central medium of inflammation, and the NF-κB signaling pathway can regulate the pro-inflammatory and coagulation response. Thus, to explore the mechanism and make use of it may provide new solutions for the prevention and treatment of thrombosis.

Citing Articles

Association between gastroesophageal reflux disease and venous thromboembolism: A Mendelian randomization study.

Ao T, Huang Y, Zhen P, Hu M Medicine (Baltimore). 2025; 103(47):e40680.

PMID: 39809153 PMC: 11596342. DOI: 10.1097/MD.0000000000040680.

Causal effect of gut microbiota on venous thromboembolism: a two-sample mendelian randomization study.

Xi L, Wang H, Du J, Liu A, Wang J, Ni Y Thromb J. 2024; 22(1):106.

PMID: 39614282 PMC: 11605883. DOI: 10.1186/s12959-024-00676-7.

Construction of a nomogram for preoperative deep vein thrombosis in pelvic fracture patients.

Li W, Ling H, Huang Z, Lao Y, Liu J, Deng G BMC Surg. 2024; 24(1):331.

PMID: 39455965 PMC: 11515835. DOI: 10.1186/s12893-024-02629-3.

TLR2 promotes traumatic deep venous thrombosis of the lower extremity following femoral fracture by activating the NF‑κB/COX‑2 signaling pathway in rats.

Guo T, Xiong L, Xie J, Zeng J, Huang Z, Yao M Exp Ther Med. 2024; 28(6):436.

PMID: 39355523 PMC: 11443593. DOI: 10.3892/etm.2024.12725.

O-GlcNAcylation: Crosstalk between Hemostasis, Inflammation, and Cancer.

Vasquez Martinez I, Perez-Campos E, Perez-Campos Mayoral L, Cruz Luis H, Pina Canseco M, Zenteno E Int J Mol Sci. 2024; 25(18).

PMID: 39337387 PMC: 11432004. DOI: 10.3390/ijms25189896.

References

Li R, Chen Y, Shi M, Xu X, Zhao Y, Wu X . Gegen Qinlian decoction alleviates experimental colitis via suppressing TLR4/NF-κB signaling and enhancing antioxidant effect. Phytomedicine. 2016; 23(10):1012-20. DOI: 10.1016/j.phymed.2016.06.010. View

Albayati M, Grover S, Saha P, Lwaleed B, Modarai B, Smith A . Postsurgical Inflammation as a Causative Mechanism of Venous Thromboembolism. Semin Thromb Hemost. 2015; 41(6):615-20. DOI: 10.1055/s-0035-1556726. View

Li C, Ai G, Wang Y, Lu Q, Luo C, Tan L . Oxyberberine, a novel gut microbiota-mediated metabolite of berberine, possesses superior anti-colitis effect: Impact on intestinal epithelial barrier, gut microbiota profile and TLR4-MyD88-NF-κB pathway. Pharmacol Res. 2019; 152:104603. DOI: 10.1016/j.phrs.2019.104603. View

Wang Q, Su Y, Sheng J, Gu L, Zhao Y, Chen X . Anti-influenza A virus activity of rhein through regulating oxidative stress, TLR4, Akt, MAPK, and NF-κB signal pathways. PLoS One. 2018; 13(1):e0191793. PMC: 5791991. DOI: 10.1371/journal.pone.0191793. View

Rasmi R, Sakthivel K, Guruvayoorappan C . NF-κB inhibitors in treatment and prevention of lung cancer. Biomed Pharmacother. 2020; 130:110569. DOI: 10.1016/j.biopha.2020.110569. View

Hunter P . Thrombosis after covid-19 vaccination. BMJ. 2021; 373:n958. DOI: 10.1136/bmj.n958. View

Kong D, Kim Y, Kim M, Jang J, Lee S . Emerging Roles of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Immunological Disorders and Cancer. Int J Mol Sci. 2018; 19(4). PMC: 5979609. DOI: 10.3390/ijms19041057. View

Lu W, Lin K, Hsu M, Chou D, Hsiao G, Sheu J . Suppression of NF-κB signaling by andrographolide with a novel mechanism in human platelets: regulatory roles of the p38 MAPK-hydroxyl radical-ERK2 cascade. Biochem Pharmacol. 2012; 84(7):914-24. DOI: 10.1016/j.bcp.2012.06.030. View

He T, Wang M, Kong J, Wang Q, Tian Y, Li C . Integrating network pharmacology and non-targeted metabolomics to explore the common mechanism of Coptis Categorized Formula improving T2DM zebrafish. J Ethnopharmacol. 2021; 284:114784. DOI: 10.1016/j.jep.2021.114784. View

10.

Urban C, Ermert D, Schmid M, Abu-Abed U, Goosmann C, Nacken W . Neutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against Candida albicans. PLoS Pathog. 2009; 5(10):e1000639. PMC: 2763347. DOI: 10.1371/journal.ppat.1000639. View

11.

Hwang J, Lee S, Lee S, Lee M, Koyanagi A, Jacob L . Comparison of vaccine-induced thrombotic events between ChAdOx1 nCoV-19 and Ad26.COV.2.S vaccines. J Autoimmun. 2021; 122:102681. PMC: 8204660. DOI: 10.1016/j.jaut.2021.102681. View

12.

Resnick N, Yahav H, Shay-Salit A, Shushy M, Schubert S, Zilberman L . Fluid shear stress and the vascular endothelium: for better and for worse. Prog Biophys Mol Biol. 2003; 81(3):177-99. DOI: 10.1016/s0079-6107(02)00052-4. View

13.

Verhamme P, Hoylaerts M . The pivotal role of the endothelium in haemostasis and thrombosis. Acta Clin Belg. 2007; 61(5):213-9. DOI: 10.1179/acb.2006.036. View

14.

Zheng X, Liu H, Ma M, Ji J, Zhu F, Sun L . Anti-thrombotic activity of phenolic acids obtained from Salvia miltiorrhiza f. alba in TNF-α-stimulated endothelial cells via the NF-κB/JNK/p38 MAPK signaling pathway. Arch Pharm Res. 2021; 44(4):427-438. DOI: 10.1007/s12272-021-01325-7. View

15.

Li W, Fan T, Zhang Y, Fan T, Zhou P, Niu X . Houttuynia cordata Thunb. volatile oil exhibited anti-inflammatory effects in vivo and inhibited nitric oxide and tumor necrosis factor-α production in LPS-stimulated mouse peritoneal macrophages in vitro. Phytother Res. 2013; 27(11):1629-39. DOI: 10.1002/ptr.4905. View

16.

Ghosh S, Hayden M . New regulators of NF-kappaB in inflammation. Nat Rev Immunol. 2008; 8(11):837-48. DOI: 10.1038/nri2423. View

17.

Lehoux S, Tedgui A . Cellular mechanics and gene expression in blood vessels. J Biomech. 2003; 36(5):631-43. DOI: 10.1016/s0021-9290(02)00441-4. View

18.

Yan Y, Fu Y, Wu S, Qin H, Zhen X, Song B . Anti-influenza activity of berberine improves prognosis by reducing viral replication in mice. Phytother Res. 2018; 32(12):2560-2567. DOI: 10.1002/ptr.6196. View

19.

Ling L, Lu Y, Zhang Y, Zhu H, Tu P, Li H . Flavonoids from Houttuynia cordata attenuate H1N1-induced acute lung injury in mice via inhibition of influenza virus and Toll-like receptor signalling. Phytomedicine. 2020; 67:153150. DOI: 10.1016/j.phymed.2019.153150. View

20.

Cheng B, Chan J, Chan B, Lin H, Han X, Zhou X . Structural characterization and immunomodulatory effect of a polysaccharide HCP-2 from Houttuynia cordata. Carbohydr Polym. 2014; 103:244-9. PMC: 7112369. DOI: 10.1016/j.carbpol.2013.12.048. View