Preparation of a Water-Soluble Glycopolymer Bearing Porphyrin Skeletons and Its Biological Properties

Overview

Journal ACS Omega

Publisher American Chemical Society

Specialty Chemistry

Date 2023 Oct 16

PMID 37841131

Authors

Yoshihiro Ishimaru

Tomohide Moteki

Miho Suzuki

Tetsuo Koyama

Takahiko Matsushita

Ken Hatano

Koji Matsuoka

Affiliations

Soon will be listed here.

Abstract

A known tetraphenyl porphyrin (TPP) having an amino functional group [5-(4-aminophenyl)-10,15,20-(triphenyl)porphyrin] was converted into the corresponding monomer by means of condensation with acryloyl chloride. Simple radical polymerization of the porphyrin monomer and a glycosyl monomer in the presence of acrylamide as a regulator monomer in order to avoid steric interference gave a water-soluble glycopolymer bearing porphyrin moieties. Spectroscopic analyses suggested incorporation of porphyrin moieties in the glycopolymer. The physical properties of the water-soluble glycopolymer bearing porphyrin moieties were examined in aqueous media, and the results also indicated the incorporation of TPP moieties in the polymer. Uptake of the polymer into HeLa cells was observed, and the cytotoxicity of the polymer was confirmed by microscopic analyses. The glycopolymer bearing porphyrin moieties is promising not only for photodynamic therapy but also as an anti-cancer reagent.

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