The Glioblastoma CircularRNAome

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Oct 14

PMID 37833993

Authors

Alexandru Tirpe

Cristian Streianu

Stefana Maria Tirpe

Anja Kocijancic

Radu Pirlog

Bianca Pirlog

Constantin Busuioc

Ovidiu-Laurean Pop

Ioana Berindan-Neagoe

Affiliations

Soon will be listed here.

Abstract

Glioblastoma remains one of the most aggressive cancers of the brain, warranting new methods for early diagnosis and more efficient treatment options. Circular RNAs (circRNAs) are rather new entities with increased stability compared to their linear counterparts that interact with proteins and act as microRNA sponges, among other functions. Herein, we provide a critical overview of the recently described glioblastoma-related circRNAs in the literature, focusing on their roles on glioblastoma cancer cell proliferation, survival, migration, invasion and metastasis, metabolic reprogramming, and therapeutic resistance. The main roles of circRNAs in regulating cancer processes are due to their regulatory roles in essential oncogenic pathways, including MAPK, PI3K/AKT/mTOR, and Wnt, which are influenced by various circRNAs. The present work pictures the wide implication of circRNAs in glioblastoma, thus highlighting their potential as future biomarkers and therapeutic targets/agents.

Citing Articles

The Role of the Dysregulation of circRNAs Expression in Glioblastoma Multiforme.

Wang Y, Yu Y, Yu J, Wang C, Wang Y, Fu R J Mol Neurosci. 2025; 75(1):9.

PMID: 39841303 DOI: 10.1007/s12031-024-02285-5.

The road to overcome pancreatic cancer: Where are we?.

Tirpe A, Streianu C, Isachesku E, Simon I, Berindan-Neagoe I Heliyon. 2024; 10(19):e38196.

PMID: 39403527 PMC: 11471497. DOI: 10.1016/j.heliyon.2024.e38196.

Circular RNA in cancer.

Conn V, Chinnaiyan A, Conn S Nat Rev Cancer. 2024; 24(9):597-613.

PMID: 39075222 DOI: 10.1038/s41568-024-00721-7.

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