Engineering Organ-on-a-Chip Systems for Vascular Diseases

Overview

Journal Arterioscler Thromb Vasc Biol

Date 2023 Oct 12

PMID 37823265

Authors

Amid Shakeri

Ying Wang

Yimu Zhao

Shira Landau

Kevin Perera

Jonguk Lee

Milica Radisic

Affiliations

Soon will be listed here.

Abstract

Vascular diseases, such as atherosclerosis and thrombosis, are major causes of morbidity and mortality worldwide. Traditional in vitro models for studying vascular diseases have limitations, as they do not fully recapitulate the complexity of the in vivo microenvironment. Organ-on-a-chip systems have emerged as a promising approach for modeling vascular diseases by incorporating multiple cell types, mechanical and biochemical cues, and fluid flow in a microscale platform. This review provides an overview of recent advancements in engineering organ-on-a-chip systems for modeling vascular diseases, including the use of microfluidic channels, ECM (extracellular matrix) scaffolds, and patient-specific cells. We also discuss the limitations and future perspectives of organ-on-a-chip for modeling vascular diseases.

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