Skin Cancer: Understanding the Journey of Transformation from Conventional to Advanced Treatment Approaches

Overview

Journal Mol Cancer

Publisher Biomed Central

Specialties Molecular Biology
Oncology

Date 2023 Oct 6

PMID 37803407

Authors

Nazeer Hasan

Arif Nadaf

Mohammad Imran

Umme Jiba

Afsana Sheikh

Waleed H Almalki

Salem Salman Almujri

Yousuf Hussain Mohammed

Prashant Kesharwani

Farhan Jalees Ahmad

Affiliations

Soon will be listed here.

Abstract

Skin cancer is a global threat to the healthcare system and is estimated to incline tremendously in the next 20 years, if not diagnosed at an early stage. Even though it is curable at an early stage, novel drug identification, clinical success, and drug resistance is another major challenge. To bridge the gap and bring effective treatment, it is important to understand the etiology of skin carcinoma, the mechanism of cell proliferation, factors affecting cell growth, and the mechanism of drug resistance. The current article focusses on understanding the structural diversity of skin cancers, treatments available till date including phytocompounds, chemotherapy, radiotherapy, photothermal therapy, surgery, combination therapy, molecular targets associated with cancer growth and metastasis, and special emphasis on nanotechnology-based approaches for downregulating the deleterious disease. A detailed analysis with respect to types of nanoparticles and their scope in overcoming multidrug resistance as well as associated clinical trials has been discussed.

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References

Reschly M, Shenefelt P . Controversies in skin surgery: electrodessication and curettage versus excision for low-risk, small, well-differentiated squamous cell carcinomas. J Drugs Dermatol. 2010; 9(7):773-6. View

Simoes M, Sousa J, Pais A . Skin cancer and new treatment perspectives: a review. Cancer Lett. 2014; 357(1):8-42. DOI: 10.1016/j.canlet.2014.11.001. View

Liu Y, Bhattarai P, Dai Z, Chen X . Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer. Chem Soc Rev. 2018; 48(7):2053-2108. PMC: 6437026. DOI: 10.1039/c8cs00618k. View

Sykes A, Wlodek C, Trickey A, Clayton G, Oakley A . Growth rate of clinically diagnosed superficial basal cell carcinoma and changes in dermoscopic features over time. Australas J Dermatol. 2020; 61(4):330-336. DOI: 10.1111/ajd.13352. View

Chinembiri T, du Plessis L, Gerber M, Hamman J, Du Plessis J . Review of natural compounds for potential skin cancer treatment. Molecules. 2014; 19(8):11679-721. PMC: 6271439. DOI: 10.3390/molecules190811679. View

Wong T, Morton C, Collier N, Haylett A, Ibbotson S, McKenna K . British Association of Dermatologists and British Photodermatology Group guidelines for topical photodynamic therapy 2018. Br J Dermatol. 2018; 180(4):730-739. DOI: 10.1111/bjd.17309. View

Wang M, Niu J, Ma H, Dad H, Shao H, Yuan T . Transdermal siRNA delivery by pH-switchable micelles with targeting effect suppress skin melanoma progression. J Control Release. 2020; 322:95-107. DOI: 10.1016/j.jconrel.2020.03.023. View

Afaq F, Katiyar S . Polyphenols: skin photoprotection and inhibition of photocarcinogenesis. Mini Rev Med Chem. 2011; 11(14):1200-15. PMC: 3288507. DOI: 10.2174/13895575111091200. View

Zhu X, Feng W, Chang J, Tan Y, Li J, Chen M . Temperature-feedback upconversion nanocomposite for accurate photothermal therapy at facile temperature. Nat Commun. 2016; 7:10437. PMC: 4742858. DOI: 10.1038/ncomms10437. View

10.

Tseng J, Wang B, Wang Y, Kuo Y, Chen J, Hour T . Caffeic acid phenethyl ester suppresses EGFR/FAK/Akt signaling, migration, and tumor growth of prostate cancer cells. Phytomedicine. 2023; 116:154860. DOI: 10.1016/j.phymed.2023.154860. View

11.

Pariser D, Houlihan A, Ferdon M, Berg J . Randomized Vehicle-Controlled Study of Short Drug Incubation Aminolevulinic Acid Photodynamic Therapy for Actinic Keratoses of the Face or Scalp. Dermatol Surg. 2016; 42(3):296-304. PMC: 5414777. DOI: 10.1097/DSS.0000000000000630. View

12.

Danish S, Gupta A, Khan U, Hasan N, Ahmad F, Warsi M . Intranasal Cerium Oxide Nanoparticles Ameliorate Cognitive Function in Rats with Alzheimer's via Anti-Oxidative Pathway. Pharmaceutics. 2022; 14(4). PMC: 9032241. DOI: 10.3390/pharmaceutics14040756. View

13.

Roozeboom M, Aardoom M, Nelemans P, Thissen M, Kelleners-Smeets N, Kuijpers D . Fractionated 5-aminolevulinic acid photodynamic therapy after partial debulking versus surgical excision for nodular basal cell carcinoma: a randomized controlled trial with at least 5-year follow-up. J Am Acad Dermatol. 2013; 69(2):280-7. DOI: 10.1016/j.jaad.2013.02.014. View

14.

Iqubal M, Iqubal A, Anjum H, Gupta M, Ali J, Baboota S . Determination of in vivo virtue of dermal targeted combinatorial lipid nanocolloidal based formulation of 5-fluorouracil and resveratrol against skin cancer. Int J Pharm. 2021; 610:121179. DOI: 10.1016/j.ijpharm.2021.121179. View

15.

Vinardell M, Mitjans M . Antitumor Activities of Metal Oxide Nanoparticles. Nanomaterials (Basel). 2017; 5(2):1004-1021. PMC: 5312892. DOI: 10.3390/nano5021004. View

16.

Pavithra P, Mehta A, Verma R . Essential oils: from prevention to treatment of skin cancer. Drug Discov Today. 2018; 24(2):644-655. DOI: 10.1016/j.drudis.2018.11.020. View

17.

Voiculescu V, Lisievici C, Lupu M, Vajaitu C, Draghici C, Popa A . Mediators of Inflammation in Topical Therapy of Skin Cancers. Mediators Inflamm. 2019; 2019:8369690. PMC: 6350587. DOI: 10.1155/2019/8369690. View

18.

Triebel F, JITSUKAWA S, Baixeras E, Roman-Roman S, Genevee C, Viegas-Pequignot E . LAG-3, a novel lymphocyte activation gene closely related to CD4. J Exp Med. 1990; 171(5):1393-405. PMC: 2187904. DOI: 10.1084/jem.171.5.1393. View

19.

Reichrath J, Saternus R, Vogt T . Endocrine actions of vitamin D in skin: Relevance for photocarcinogenesis of non-melanoma skin cancer, and beyond. Mol Cell Endocrinol. 2017; 453:96-102. DOI: 10.1016/j.mce.2017.05.001. View

20.

Zhou B, Song J, Wang M, Wang X, Wang J, Howard E . BSA-bioinspired gold nanorods loaded with immunoadjuvant for the treatment of melanoma by combined photothermal therapy and immunotherapy. Nanoscale. 2018; 10(46):21640-21647. PMC: 6265078. DOI: 10.1039/c8nr05323e. View