Research Progress of the Paraventricular Thalamus in the Regulation of Sleep-wake and Emotional Behaviors

Overview

Journal Ibrain

Specialty Neurology

Date 2023 Oct 3

PMID 37786895

Authors

Xiao-Li Bu

Cheng-Xi Liu

Bao Fu

Affiliations

Soon will be listed here.

Abstract

The paraventricular thalamus (PVT) is a major component of the midline structure of the thalamus. It is one of the nonspecific nuclei of the thalamus, which plays a great role in the regulation of cortical arousal. PVT, an important node in the central nervous system, sends widespread outputs to many brain regions and also accepts plentiful inputs from many brain regions to modulate diverse functions, including sleep-wake state, attention, memory, and pain. Recently, with the increasing prevalence of sleep disorders and mood disorders, people pay great attention to PVT, which was implicated in arousal and emotional behaviors. Therefore, the main purpose of this review is to illustrate the characteristic of PVT to provide a reference for future research.

Citing Articles

Chronic pain as an emergent property of a complex system and the potential roles of psychedelic therapies.

Armstrong M, Castellanos J, Christie D Front Pain Res (Lausanne). 2024; 5:1346053.

PMID: 38706873 PMC: 11066302. DOI: 10.3389/fpain.2024.1346053.

Research progress of the paraventricular thalamus in the regulation of sleep-wake and emotional behaviors.

Bu X, Liu C, Fu B Ibrain. 2023; 8(2):219-226.

PMID: 37786895 PMC: 10529009. DOI: 10.1002/ibra.12034.

Structural and functional organization of the midline and intralaminar nuclei of the thalamus.

Vertes R, Linley S, Rojas A Front Behav Neurosci. 2022; 16:964644.

PMID: 36082310 PMC: 9445584. DOI: 10.3389/fnbeh.2022.964644.

References

Choudhary A, Somalwar A, Sagarkar S, Rale A, Sakharkar A, Subhedar N . CART neurons in the lateral hypothalamus communicate with the nucleus accumbens shell via glutamatergic neurons in paraventricular thalamic nucleus to modulate reward behavior. Brain Struct Funct. 2017; 223(3):1313-1328. DOI: 10.1007/s00429-017-1544-6. View

Ahmed N, Headley D, Pare D . Optogenetic study of central medial and paraventricular thalamic projections to the basolateral amygdala. J Neurophysiol. 2021; 126(4):1234-1247. PMC: 8560422. DOI: 10.1152/jn.00253.2021. View

Matyas F, Komlosi G, Babiczky A, Kocsis K, Bartho P, Barsy B . A highly collateralized thalamic cell type with arousal-predicting activity serves as a key hub for graded state transitions in the forebrain. Nat Neurosci. 2018; 21(11):1551-1562. PMC: 6441588. DOI: 10.1038/s41593-018-0251-9. View

Kolaj M, Zhang L, Hermes M, Renaud L . Intrinsic properties and neuropharmacology of midline paraventricular thalamic nucleus neurons. Front Behav Neurosci. 2014; 8:132. PMC: 4029024. DOI: 10.3389/fnbeh.2014.00132. View

Bu X, Liu C, Fu B . Research progress of the paraventricular thalamus in the regulation of sleep-wake and emotional behaviors. Ibrain. 2023; 8(2):219-226. PMC: 10529009. DOI: 10.1002/ibra.12034. View

Moga M, Moore R . Organization of neural inputs to the suprachiasmatic nucleus in the rat. J Comp Neurol. 1997; 389(3):508-34. DOI: 10.1002/(sici)1096-9861(19971222)389:3<508::aid-cne11>3.0.co;2-h. View

Li S, Kirouac G . Sources of inputs to the anterior and posterior aspects of the paraventricular nucleus of the thalamus. Brain Struct Funct. 2011; 217(2):257-73. DOI: 10.1007/s00429-011-0360-7. View

Vertes R, Hoover W . Projections of the paraventricular and paratenial nuclei of the dorsal midline thalamus in the rat. J Comp Neurol. 2008; 508(2):212-37. DOI: 10.1002/cne.21679. View

Llinas R, Steriade M . Bursting of thalamic neurons and states of vigilance. J Neurophysiol. 2006; 95(6):3297-308. DOI: 10.1152/jn.00166.2006. View

10.

Zhang L, Renaud L, Kolaj M . Properties of a T-type Ca2+channel-activated slow afterhyperpolarization in thalamic paraventricular nucleus and other thalamic midline neurons. J Neurophysiol. 2009; 101(6):2741-50. DOI: 10.1152/jn.91183.2008. View

11.

Otis J, Zhu M, Namboodiri V, Cook C, Kosyk O, Matan A . Paraventricular Thalamus Projection Neurons Integrate Cortical and Hypothalamic Signals for Cue-Reward Processing. Neuron. 2019; 103(3):423-431.e4. PMC: 6773659. DOI: 10.1016/j.neuron.2019.05.018. View

12.

Knapp D, Duncan G, Crews F, Breese G . Induction of Fos-like proteins and ultrasonic vocalizations during ethanol withdrawal: further evidence for withdrawal-induced anxiety. Alcohol Clin Exp Res. 1998; 22(2):481-93. View

13.

Hermann D, Siccoli M, Brugger P, Wachter K, Mathis J, Achermann P . Evolution of neurological, neuropsychological and sleep-wake disturbances after paramedian thalamic stroke. Stroke. 2007; 39(1):62-8. DOI: 10.1161/STROKEAHA.107.494955. View

14.

Arcelli P, Frassoni C, Regondi M, De Biasi S, Spreafico R . GABAergic neurons in mammalian thalamus: a marker of thalamic complexity?. Brain Res Bull. 1997; 42(1):27-37. DOI: 10.1016/s0361-9230(96)00107-4. View

15.

Cheng J, Wang J, Ma X, Ullah R, Shen Y, Zhou Y . Anterior Paraventricular Thalamus to Nucleus Accumbens Projection Is Involved in Feeding Behavior in a Novel Environment. Front Mol Neurosci. 2018; 11:202. PMC: 5999750. DOI: 10.3389/fnmol.2018.00202. View

16.

Gao C, Leng Y, Ma J, Rooke V, Rodriguez-Gonzalez S, Ramakrishnan C . Two genetically, anatomically and functionally distinct cell types segregate across anteroposterior axis of paraventricular thalamus. Nat Neurosci. 2020; 23(2):217-228. PMC: 7007348. DOI: 10.1038/s41593-019-0572-3. View

17.

Balercia G, Bentivoglio M, Kruger L . Fine structural organization of the ependymal region of the paraventricular nucleus of the rat thalamus and its relation with projection neurons. J Neurocytol. 1992; 21(2):105-19. DOI: 10.1007/BF01189009. View

18.

Moruzzi G, Magoun H . Brain stem reticular formation and activation of the EEG. 1949. J Neuropsychiatry Clin Neurosci. 1995; 7(2):251-67. DOI: 10.1176/jnp.7.2.251. View

19.

Fortin M, Asselin M, Gould P, Parent A . Calretinin-immunoreactive neurons in the human thalamus. Neuroscience. 1998; 84(2):537-48. DOI: 10.1016/s0306-4522(97)00486-7. View

20.

Tian Q, Studenski S, Montero-Odasso M, Davatzikos C, Resnick S, Ferrucci L . Cognitive and neuroimaging profiles of older adults with dual decline in memory and gait speed. Neurobiol Aging. 2020; 97:49-55. DOI: 10.1016/j.neurobiolaging.2020.10.002. View