UCSF ChimeraX: Tools for Structure Building and Analysis

Overview

Journal Protein Sci

Specialty Biochemistry

Date 2023 Sep 29

PMID 37774136

Authors

Elaine C Meng

Thomas D Goddard

Eric F Pettersen

Greg S Couch

Zach J Pearson

John H Morris

Thomas E Ferrin

Affiliations

Soon will be listed here.

Abstract

Advances in computational tools for atomic model building are leading to accurate models of large molecular assemblies seen in electron microscopy, often at challenging resolutions of 3-4 Å. We describe new methods in the UCSF ChimeraX molecular modeling package that take advantage of machine-learning structure predictions, provide likelihood-based fitting in maps, and compute per-residue scores to identify modeling errors. Additional model-building tools assist analysis of mutations, post-translational modifications, and interactions with ligands. We present the latest ChimeraX model-building capabilities, including several community-developed extensions. ChimeraX is available free of charge for noncommercial use at https://www.rbvi.ucsf.edu/chimerax.

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