The Oncogenic Role of SAMMSON LncRNA in Tumorigenesis: A Comprehensive Review with Especial Focus on Melanoma

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2023 Sep 29

PMID 37772815

Authors

Majid Ghasemian

Hossein Babaahmadi-Rezaei

Azam Khedri

Chandrabose Selvaraj

Affiliations

Soon will be listed here.

Abstract

LncRNA Survival Associated Mitochondrial Melanoma Specific Oncogenic Non-coding RNA (SAMMSON) is located on human chromosome 3p13, and its expression is upregulated in several tumours, including melanoma, breast cancer, glioblastoma and liver cancer and has an oncogenic role in malignancy disorders. It has been reported that SAMMSON impacts metabolic regulation, cell proliferation, apoptosis, EMT, drug resistance, invasion and migration. Also, SAMMSON is involved in regulating several pathways such as Wnt, MAPK, PI3K, Akt, ERK and p53. SAMMSON is considered a potential diagnostic and prognostic biomarker in several types of cancer and a suitable therapeutic target. In addition, the highly expressed SAMMSON is closely associated with clinicopathological features of various cancers. SAMMSON has a significant role in regulating epigenetic processes by regulating histone protein or the status of DNA methylation. Herein for the first time, we comprehensively summarized the currently available SAMMSON, molecular regulatory pathways, and clinical significance. We believe that clarifying all the molecular aspects of this lncRNA can be a good guide for cancer studies in the future.

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