A -specific Adhesin, Scf1 Governs Surface Association, Colonization, and Virulence

Overview

Journal Science

Specialty Science

Date 2023 Sep 28

PMID 37769084

Authors

Darian J Santana

Juliet A E Anku

Guolei Zhao

Robert Zarnowski

Chad J Johnson

Haley Hautau

Noelle D Visser

Ashraf S Ibrahim

David Andes

Jeniel E Nett

Shakti Singh

Teresa R OMeara

Affiliations

Soon will be listed here.

Abstract

is an emerging fungal pathogen responsible for health care-associated outbreaks that arise from persistent surface and skin colonization. We characterized the arsenal of adhesins used by and discovered an uncharacterized adhesin, Surface Colonization Factor (Scf1), and a conserved adhesin, Iff4109, that are essential for the colonization of inert surfaces and mammalian hosts. is apparently specific to , and its expression mediates adhesion to inert and biological surfaces across isolates from all five clades. Unlike canonical fungal adhesins, which function through hydrophobic interactions, Scf1 relies on exposed cationic residues for surface association. is required for biofilm formation, skin colonization, virulence in systemic infection, and colonization of inserted medical devices.

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