Application of Quinoline Ring in Structural Modification of Natural Products

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2023 Sep 28

PMID 37764254

Authors

Yu-Qing Zhao

Xiaoting Li

Hong-Yan Guo

Qing-Kun Shen

Zhe-Shan Quan

Tian Luan

Affiliations

Soon will be listed here.

Abstract

Natural compounds are rich in pharmacological properties that are a hot topic in pharmaceutical research. The quinoline ring plays important roles in many biological processes in heterocycles. Many pharmacological compounds, including saquinavir and chloroquine, have been marketed as quinoline molecules with good anti-viral and anti-parasitic properties. Therefore, in this review, we summarize the medicinal chemistry of quinoline-modified natural product quinoline derivatives that were developed by several research teams in the past 10 years and find that these compounds have inhibitory effects on bacteria, viruses, parasites, inflammation, cancer, Alzheimer's disease, and others.

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