The Role of Fecal Microbiota Transplantation in the Allogeneic Stem Cell Transplant Setting

Overview

Journal Microorganisms

Specialty Microbiology

Date 2023 Sep 28

PMID 37764025

Authors

Elisabetta Metafuni

Luca Di Marino

Sabrina Giammarco

Silvia Bellesi

Maria Assunta Limongiello

Federica Sora

Filippo Frioni

Roberto Maggi

Patrizia Chiusolo

Simona Sica

Affiliations

Soon will be listed here.

Abstract

Microbiota changes during allogeneic hematopoietic stem cell transplantation has several known causes: conditioning chemotherapy and radiation, broad-spectrum antibiotic administration, modification in nutrition status and diet, and graft-versus-host disease. This article aims to review the current knowledge about the close link between microbiota and allogeneic stem cell transplantation setting. The PubMed search engine was used to perform this review. We analyzed data on microbiota dysbiosis related to the above-mentioned affecting factors. We also looked at treatments aimed at modifying gut dysbiosis and applications of fecal microbiota transplantation in the allogeneic stem cell transplant field, with particular interest in fecal microbiota transplantation for graft-versus-host disease (GvHD), multidrug-resistant and clostridium difficile infections, and microbiota restoration after chemotherapy and antibiotic therapy.

Citing Articles

Gut microbiota and graft-versus-host disease in hematopoietic stem cell transplant patients.

Panahi P, Hashemian A, Payandeh M, Taghadosi M, Nomanpour B Iran J Microbiol. 2024; 16(5):648-654.

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Gut Microbiota Disruption in Hematologic Cancer Therapy: Molecular Insights and Implications for Treatment Efficacy.

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Alteration of Gut Microbiota Composition and Diversity in Acute and/or Chronic Graft-versus-Host Disease Following Hematopoietic Stem Cell Transplantation: A Prospective Cohort Study.

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Next-Generation Sequencing-Based Monitoring of Intestinal Bacteria and Bacteriophages Following Fecal Microbiota Transplantation in Inflammatory Bowel Diseases.

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