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Sea Cucumber Peptide Alleviates Ulcerative Colitis Induced by Dextran Sulfate Sodium by Alleviating Gut Microbiota Imbalance and Regulating MiR-155/SOCS1 Axis in Mice

Overview
Journal Foods
Specialty Biotechnology
Date 2023 Sep 28
PMID 37761144
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Abstract

Sea cucumber peptides have been proven to exhibit a variety of biological activities. Ulcerative colitis (UC) is a chronic disease characterized by diffuse inflammation of the mucosa of the rectum and colon with increasing incidence and long duration, and is difficult to cure. The effect of sea cucumber peptide on UC is currently unknown. In this study, 1.5% dextran sulfate sodium (DSS) was added to the drinking water of mice to induce a UC model, and the daily doses of sea cucumber peptide (SP) solution of 200 mg/kg·BW, 500 mg/kg·BW, and 1000 mg/kg·BW were given to UC mice to detect the relieving effect of SP. The results showed that SP can reduce the disease activity index (DAI) of UC mice induced by DSS and can alleviate colon shortening, intestinal tissue damage, and the loss of intestinal tight junction proteins (Claudin-1, Occludin). SP decreased the spleen index, pro-inflammatory factors (IL-1β, IL-6, TNF-α), and myeloperoxidase (MPO) levels in UC mice. SP can alleviate the imbalance of gut microbiota in UC mice, increase the abundance of the , , and , and reduce the abundance of and the , as well as alleviating the decrease in short-chain fatty acid (SCFA) content in the feces of UC mice. Notably, SP inhibited miR-155 expression in the colon tissue of UC mice and increased its target protein, suppressor of cytokine signaling 1 (SOCS1), which acts as an inflammatory inhibitor. In summary, the ameliorative effect of SP on UC may be achieved by improving the imbalance of gut microbiota and regulating the miR-155/SOCS1 axis. This study provides a new idea for developing SP as a nutritional supplement to maintain intestinal health.

Citing Articles

Oyster Peptides Ameliorate Dextran Sulfate Sodium-Induced Ulcerative Colitis via Modulating the Gut Microbiota and Inhibiting the TLR4/NF-κB Pathway.

Guo H, Xie W, Ji Z, Wang B, Ren W, Gao W Nutrients. 2024; 16(11).

PMID: 38892524 PMC: 11175164. DOI: 10.3390/nu16111591.


Sea Cucumber Peptides Ameliorate DSS-Induced Ulcerative Colitis: The Role of the Gut Microbiota, the Intestinal Barrier, and Macrophage Polarization.

Yu S, Guo H, Ji Z, Zheng Y, Wang B, Chen Q Nutrients. 2023; 15(22).

PMID: 38004208 PMC: 10674221. DOI: 10.3390/nu15224813.

References
1.
Zhao B, Xia B, Li X, Zhang L, Liu X, Shi R . Sesamol Supplementation Attenuates DSS-Induced Colitis via Mediating Gut Barrier Integrity, Inflammatory Responses, and Reshaping Gut Microbiome. J Agric Food Chem. 2020; 68(39):10697-10708. DOI: 10.1021/acs.jafc.0c04370. View

2.
Cosnes J, Gower-Rousseau C, Seksik P, Cortot A . Epidemiology and natural history of inflammatory bowel diseases. Gastroenterology. 2011; 140(6):1785-94. DOI: 10.1053/j.gastro.2011.01.055. View

3.
Li N, Ouyang Y, Xu X, Yuan Z, Liu C, Zhu Z . MiR-155 promotes colitis-associated intestinal fibrosis by targeting HBP1/Wnt/β-catenin signalling pathway. J Cell Mol Med. 2021; 25(10):4765-4775. PMC: 8107084. DOI: 10.1111/jcmm.16445. View

4.
Neurath M . Targeting immune cell circuits and trafficking in inflammatory bowel disease. Nat Immunol. 2019; 20(8):970-979. DOI: 10.1038/s41590-019-0415-0. View

5.
De Vadder F, Kovatcheva-Datchary P, Goncalves D, Vinera J, Zitoun C, Duchampt A . Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits. Cell. 2014; 156(1-2):84-96. DOI: 10.1016/j.cell.2013.12.016. View