Lipid-Lowering Effects of a Novel Polysaccharide Obtained from Fuzhuan Brick Tea In Vitro

Overview

Journal Foods

Specialty Biotechnology

Date 2023 Sep 28

PMID 37761137

Authors

Wenjuan Yang

Shirui Cheng

Meng Liu

Nan Li

Jing Wang

Wenbo Yao

Fuxin Chen

Jianwu Xie

Pin Gong

Affiliations

Soon will be listed here.

Abstract

Lipid accumulation causes diseases such as obesity and abnormal lipid metabolism, thus impairing human health. Tea polysaccharide is one of the natural, active substances that can lower lipid levels. In this paper, an oleic-acid-induced HepG2 cell model was established. The lipid-lowering effects of a novel group of Fuzhuan brick tea polysaccharides (FTPs)-obtained from Fuzhuan brick tea-were examined in vitro. The monosaccharide composition of FTP3 was Glc, Gal, Ara, Man, Rha, GalAc, GlcAc, and Xyl with a molar ratio of 23.5:13.2:9.0:5.5:5.4:2.7:1.3:1.0, respectively. A molecular weight of 335.68 kDa was identified for FTP3. HepG2 cells treated with FTP3 achieved a prominent lipid-lowering effect compared with cells treated with oleic acid. Images of the Oil Red O staining treatment showed that FTP3-treated groups had significantly fewer red fat droplets. TC and TG levels were lower in FTP3-treated groups. FTP3 alleviated lipid accumulation in HepG2 cells, activated AMPK, and decreased the SREBP-1C and FAS protein expressions associated with fatty acid synthesis. FTP3 holds promising potential for its lipid-lowering effects.

Citing Articles

Global hotspots and trends in tea anti-obesity research: a bibliometric analysis from 2004 to 2024.

Liu S, Fan B, Li X, Sun G Front Nutr. 2024; 11:1496582.

PMID: 39606571 PMC: 11598529. DOI: 10.3389/fnut.2024.1496582.

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