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Effect of Carcinomas on Autosomal Trait Screening: A Review Article

Overview
Publisher MDPI
Specialty Molecular Biology
Date 2023 Sep 27
PMID 37754244
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Abstract

This review highlights the effect of carcinomas on the results of the examination of autosomal genetic traits for identification and paternity tests when carcinoid tissue is the only source and no other samples are available. In DNA typing or genetic fingerprinting, variable elements are isolated and identified within the base pair sequences that form the DNA. The person's probable identity can be determined by analysing nucleotide sequences in particular regions of DNA unique to everyone. Genetics plays an increasingly important role in the risk stratification and management of carcinoma patients. The available information from previous studies has indicated that in some incidents, including mass disasters and crimes such as terrorist incidents, biological evidence may not be available at the scene of the accident, except for some unknown human remains found in the form of undefined human tissues. If these tissues have cancerous tumours, it may affect the examination of the genetic traits derived from these samples, thereby resulting in a failure to identify the person. Pathology units, more often, verify the identity of the patients who were diagnosed with cancer in reference to their deceased tumorous relatives. Genetic fingerprinting (GF) is also used in paternity testing when the alleged parent disappeared or died and earlier was diagnosed and treated for cancer.

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References
1.
Alharbi S, Alamri A, Elshehawi A . The Impact of Leukemia on the Detection of Short Tandem Repeat (STR) Markers. Cureus. 2022; 14(11):e30954. PMC: 9711926. DOI: 10.7759/cureus.30954. View

2.
Risinskaya N, Kozhevnikova Y, Gavrilina O, Chabaeva J, Kotova E, Yushkova A . Loss of Heterozygosity in the Tumor DNA of De Novo Diagnosed Patients Is Associated with Poor Outcome for B-ALL but Not for T-ALL. Genes (Basel). 2022; 13(3). PMC: 8952291. DOI: 10.3390/genes13030398. View

3.
Audano P, Sulovari A, Graves-Lindsay T, Cantsilieris S, Sorensen M, Welch A . Characterizing the Major Structural Variant Alleles of the Human Genome. Cell. 2019; 176(3):663-675.e19. PMC: 6438697. DOI: 10.1016/j.cell.2018.12.019. View

4.
Wyner N, Barash M, McNevin D . Forensic Autosomal Short Tandem Repeats and Their Potential Association With Phenotype. Front Genet. 2020; 11:884. PMC: 7425049. DOI: 10.3389/fgene.2020.00884. View

5.
Chen M, Chen J, Hu J, Chen Q, Yu L, Liu B . Comparison of microsatellite status detection methods in colorectal carcinoma. Int J Clin Exp Pathol. 2020; 11(3):1431-1438. PMC: 6958115. View