Molecular Mechanisms of Colistin- and Multidrug-resistance in Bacteria Among Patients with Hospital-acquired Infections

Overview

Journal Future Sci OA

Specialty Biotechnology

Date 2023 Sep 27

PMID 37753358

Authors

Surbhi Khurana

Amit Katiyar

Mamta Puraswani

Divya Sharma

Kamini Walia

Rajesh Malhotra

Purva Mathur

Affiliations

Soon will be listed here.

Abstract

Aim: The increasing burden of resistance in Gram-negative bacteria (GNB) is becoming a major issue for hospital-acquired infections. Therefore, understanding the molecular mechanisms is important.

Methodology: Resistance genes of phenotypically colistin-resistant GNB (n = 60) were determined using whole genome sequencing. Antimicrobial susceptibility patterns were detected by Vitek®2 & broth microdilution.

Results: Of these phenotypically colistin-resistant isolates, 78% were also genetically resistant to colistin. Activation of efflux pumps, and point-mutations in , and genes conferred colistin resistance among GNB. Eight different strains of were identified and ST43 was the most prominent strain with capsular type-specific (cps) gene KL30.

Discussion: These results, in combination with rapid diagnostic methods, will help us better advice appropriate antimicrobial regimens.

Citing Articles

An Overview of the Genetic Mechanisms of Colistin-Resistance in Bacterial Pathogens: An Indian Perspective.

Yadav K, Datkhile K, Pawar S, Patil S Cureus. 2025; 17(2):e78800.

PMID: 40078264 PMC: 11902915. DOI: 10.7759/cureus.78800.

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