The Mechanisms and Factors That Induce Trained Immunity in Arthropods and Mollusks

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2023 Sep 25

PMID 37744346

Authors

Mingming Zhao

Zhongyang Lin

Zhihong Zheng

Defu Yao

Shen Yang

Yongzhen Zhao

Xiuli Chen

Jude Juventus Aweya

Yueling Zhang

Affiliations

Soon will be listed here.

Abstract

Besides dividing the organism's immune system into adaptive and innate immunity, it has long been thought that only adaptive immunity can establish immune memory. However, many studies have shown that innate immunity can also build immunological memory through epigenetic reprogramming and modifications to resist pathogens' reinfection, known as trained immunity. This paper reviews the role of mitochondrial metabolism and epigenetic modifications and describes the molecular foundation in the trained immunity of arthropods and mollusks. Mitochondrial metabolism and epigenetic modifications complement each other and play a key role in trained immunity.

Citing Articles

DNA Methylation Machinery in Gastropod Mollusks.

Haidar L, Georgescu M, Draghici G, Banatean-Dunea I, Nica D, Serb A Life (Basel). 2024; 14(4).

PMID: 38672807 PMC: 11050768. DOI: 10.3390/life14040537.

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