Positive Additive Interaction Effects of Age, Sex, Obesity, and Metabolic Syndrome on Left Ventricular Dysfunction

Overview

Journal J Diabetes

Specialty Endocrinology

Date 2023 Sep 24

PMID 37743094

Authors

Dan Zhou

Zhongwen Ye

Zhiqiang Nie

Chaolei Chen

Songyuan Luo

Mengqi Yan

Jiabin Wang

Yingqing Feng

Affiliations

Soon will be listed here.

Abstract

Objective: This study aims to explore the association between metabolic syndrome (MetS) and left ventricular diastolic dysfunction (LVDD) and systolic dysfunction (LVSD), defined by impaired global longitudinal strain (GLS), and assess additive and multiplicative interactions among age, sex, obesity, and MetS regarding LVDD and LVSD.

Methods: We prospectively recruited 5503 participants from the China PEACE (Patient-Centered Evaluative Assessment of Cardiac Events) Million Persons Project with complete echocardiography exam. Multivariable logistic models were used to calculate adjusted odds ratios to evaluate both additive and multiplicative interactions.

Results: The mean age was 56.59 years; 59.4% were women, 46.7% had MetS, 26.6% had left ventricular hypertrophy, 46.3% had LVDD, and 12.50% had impaired GLS. Compared to the non-MetS, the odds ratio (OR) of LVDD and impaired GLS in MetS were 1.40 (1.20-1.64) and 1.26 (1.03-1.54), respectively. For LVDD, relative excess risk due to additive interaction (RERI) for women and MetS, elderly and MetS, obesity and MetS were 0.76 (0.02-1.50), 35.65 (17.51-53.79), and 2.14 (0.66-3.62), respectively, thus suggesting additive interactions. For impaired GLS, RERI for obesity and MetS was 3.37 (0.50-6.24), thus suggesting additive interactions.

Conclusions: The MetS is independently associated with LVDD and impaired GLS. From the public health implications, prevention of MetS in women, elderly, and obese individuals might result in a greater reduction of LVDD and LVSD risk in cardiovascular high-risk population.

Citing Articles

Assessing coronary artery stenosis exacerbated impact on left ventricular function and deformation in metabolic syndrome patients by 3.0 T cardiac magnetic resonance imaging.

Jiang Y, Gao Y, Min C, Guo Y, Xu R, Shen L Cardiovasc Diabetol. 2024; 23(1):414.

PMID: 39558352 PMC: 11575079. DOI: 10.1186/s12933-024-02492-9.

Positive additive interaction effects of age, sex, obesity, and metabolic syndrome on left ventricular dysfunction.

Zhou D, Ye Z, Nie Z, Chen C, Luo S, Yan M J Diabetes. 2023; 16(1):e13478.

PMID: 37743094 PMC: 10809287. DOI: 10.1111/1753-0407.13478.

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