DeepSlice: Rapid Fully Automatic Registration of Mouse Brain Imaging to a Volumetric Atlas

Overview

Journal Nat Commun

Specialty Biology

Date 2023 Sep 22

PMID 37735467

Authors

Harry Carey

Michael Pegios

Lewis Martin

Chris Saleeba

Anita J Turner

Nicholas A Everett

Ingvild E Bjerke

Maja A Puchades

Jan G Bjaalie

Simon McMullan

Affiliations

Soon will be listed here.

Abstract

Registration of data to a common frame of reference is an essential step in the analysis and integration of diverse neuroscientific data. To this end, volumetric brain atlases enable histological datasets to be spatially registered and analyzed, yet accurate registration remains expertise-dependent and slow. In order to address this limitation, we have trained a neural network, DeepSlice, to register mouse brain histological images to the Allen Brain Common Coordinate Framework, retaining registration accuracy while improving speed by >1000 fold.

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