Apelin-13 Alleviates Contrast-induced Acute Kidney Injury by Inhibiting Endoplasmic Reticulum Stress

Overview

Journal Ren Fail

Publisher Informa Healthcare

Date 2023 Sep 18

PMID 37723076

Authors

Qian Liu

Shao-Bin Duan

Lin Wang

Xiao-Qin Luo

Hong-Shen Wang

Ying-Hao Deng

Xi Wu

Ting Wu

Ping Yan And

Yi-Xin Kang

Affiliations

Soon will be listed here.

Abstract

Contrast-induced acute kidney injury (CI-AKI) is a severe complication associated with significant morbidity and mortality, and effective therapeutic strategies are still lacking. Apelin is an endogenous physiological regulator with antioxidative, anti-inflammatory and antiapoptotic properties. However, the role of apelin-13 in CI-AKI remains unclear. In our study, we found that the protein expression levels of apelin were significantly downregulated in rat kidney tissues and HK-2 cells during contrast media treatment. Moreover, we explored the protective effect of apelin-13 on renal tubule damage using and models of CI-AKI. Exogenous apelin-13 ameliorated endoplasmic reticulum stress, reactive oxygen species and apoptosis protein expression in contrast media-treated cells and rat kidney tissues. Mechanistically, the downregulation of endoplasmic reticulum stress contributed critically to the antiapoptotic effect of apelin-13. Collectively, our findings reveal the inherent mechanisms by which apelin-13 regulates CI-AKI and provide a prospective target for the prevention of CI-AKI.

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References

Nijssen E, Rennenberg R, Nelemans P, Essers B, Janssen M, Vermeeren M . Prophylactic hydration to protect renal function from intravascular iodinated contrast material in patients at high risk of contrast-induced nephropathy (AMACING): a prospective, randomised, phase 3, controlled, open-label, non-inferiority trial. Lancet. 2017; 389(10076):1312-1322. DOI: 10.1016/S0140-6736(17)30057-0. View

Xu W, Li T, Gao L, Zheng J, Yan J, Zhang J . Apelin-13/APJ system attenuates early brain injury via suppression of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation and oxidative stress in a AMPK-dependent manner after subarachnoid hemorrhage in rats. J Neuroinflammation. 2019; 16(1):247. PMC: 6889224. DOI: 10.1186/s12974-019-1620-3. View

Huang Z, Wu L, Chen L . Apelin/APJ system: A novel potential therapy target for kidney disease. J Cell Physiol. 2017; 233(5):3892-3900. DOI: 10.1002/jcp.26144. View

Falcao-Pires I, Ladeiras-Lopes R, Leite-Moreira A . The apelinergic system: a promising therapeutic target. Expert Opin Ther Targets. 2010; 14(6):633-45. DOI: 10.1517/14728221003752743. View

Cullinan S, Diehl J . Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway. Int J Biochem Cell Biol. 2005; 38(3):317-32. DOI: 10.1016/j.biocel.2005.09.018. View

Li Y, Li Y, Li Y, Yang Z, Geng H, Liu C . Inhibition of endoplasmic reticulum stress mediates the ameliorative effect of apelin on vascular calcification. J Mol Cell Cardiol. 2020; 152:17-28. DOI: 10.1016/j.yjmcc.2020.11.017. View

Zhao F, Feng L, Liu Q, Wang H, Tang C, Cheng W . Stanniocalcin-1 Alleviates Contrast-Induced Acute Kidney Injury by Regulating Mitochondrial Quality Control via the Nrf2 Pathway. Oxid Med Cell Longev. 2020; 2020:1898213. PMC: 7153002. DOI: 10.1155/2020/1898213. View

Peng P, Ma Q, Wang L, Zhang O, Han H, Liu X . Preconditioning With Tauroursodeoxycholic Acid Protects Against Contrast-Induced HK-2 Cell Apoptosis by Inhibiting Endoplasmic Reticulum Stress. Angiology. 2015; 66(10):941-9. DOI: 10.1177/0003319715575965. View

Yang L, Xing G, Wang L, Wu Y, Li S, Xu G . Acute kidney injury in China: a cross-sectional survey. Lancet. 2015; 386(10002):1465-71. DOI: 10.1016/S0140-6736(15)00344-X. View

10.

Yang Y, Yang D, Yang D, Jia R, Ding G . Role of reactive oxygen species-mediated endoplasmic reticulum stress in contrast-induced renal tubular cell apoptosis. Nephron Exp Nephrol. 2014; 128(1-2):30-6. DOI: 10.1159/000366063. View

11.

Shu S, Zhu J, Liu Z, Tang C, Cai J, Dong Z . Endoplasmic reticulum stress is activated in post-ischemic kidneys to promote chronic kidney disease. EBioMedicine. 2018; 37:269-280. PMC: 6286638. DOI: 10.1016/j.ebiom.2018.10.006. View

12.

Cheng W, Wu X, Liu Q, Wang H, Zhang N, Xiao Y . Post-contrast acute kidney injury in a hospitalized population: short-, mid-, and long-term outcome and risk factors for adverse events. Eur Radiol. 2020; 30(6):3516-3527. PMC: 7248019. DOI: 10.1007/s00330-020-06690-3. View

13.

Zhang Z, Zhang L, Zhou L, Lei Y, Zhang Y, Huang C . Redox signaling and unfolded protein response coordinate cell fate decisions under ER stress. Redox Biol. 2018; 25:101047. PMC: 6859529. DOI: 10.1016/j.redox.2018.11.005. View

14.

Verfaillie T, Rubio N, Garg A, Bultynck G, Rizzuto R, Decuypere J . PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress. Cell Death Differ. 2012; 19(11):1880-91. PMC: 3469056. DOI: 10.1038/cdd.2012.74. View

15.

Fahling M, Seeliger E, Patzak A, Persson P . Understanding and preventing contrast-induced acute kidney injury. Nat Rev Nephrol. 2017; 13(3):169-180. DOI: 10.1038/nrneph.2016.196. View

16.

Wu F, Qiu J, Fan Y, Zhang Q, Cheng B, Wu Y . Apelin-13 attenuates ER stress-mediated neuronal apoptosis by activating Gα/Gα-CK2 signaling in ischemic stroke. Exp Neurol. 2018; 302:136-144. DOI: 10.1016/j.expneurol.2018.01.006. View

17.

Cheng W, Li X, Xiao Y, Duan S . Non-coding RNA-Associated ceRNA Networks in a New Contrast-Induced Acute Kidney Injury Rat Model. Mol Ther Nucleic Acids. 2019; 17:102-112. PMC: 6595412. DOI: 10.1016/j.omtn.2019.05.011. View

18.

Wu C, Weng T, Chen L, Chiang C, Liu S . Involvement of caspase-12-dependent apoptotic pathway in ionic radiocontrast urografin-induced renal tubular cell injury. Toxicol Appl Pharmacol. 2012; 266(1):167-75. DOI: 10.1016/j.taap.2012.10.012. View

19.

Eng J, Wilson R, Subramaniam R, Zhang A, Suarez-Cuervo C, Turban S . Comparative Effect of Contrast Media Type on the Incidence of Contrast-Induced Nephropathy: A Systematic Review and Meta-analysis. Ann Intern Med. 2016; 164(6):417-24. DOI: 10.7326/M15-1402. View

20.

Lu X, Liu S, Luan R, Cui W, Chen Y, Zhang Y . Serum elabela and apelin levels during different stages of chronic kidney disease. Ren Fail. 2020; 42(1):667-672. PMC: 7470108. DOI: 10.1080/0886022X.2020.1792926. View