An Overview of Colistin Resistance: A Breach in Last Line Defense

Overview

Journal Med J Armed Forces India

Specialty General Medicine

Date 2023 Sep 18

PMID 37719908

Authors

Bidyut Prava Rout

Birasen Behera

Kundan Kumar Sahu

Ira Praharaj

Sarita Otta

Affiliations

Soon will be listed here.

Abstract

Rising prevalence of antibiotic resistance and the unavailability of newer drugs to tackle this menace is one of the major hindrances to the goal of health and well-being set up by the General Assembly of the United Nations. The genes responsible for this resistance are often disseminated from hospitals to different environmental sources. In 2015, for the first time, resistance to Colistin was detected caused by chromosomal genetic mutations. Later, plasmid-mediated colistin resistance (MCR-1 to MCR-10) was detected, first from China and then from various other countries. As per Clinical and Laboratory Standards Institute (CLSI), commonly available diffusion techniques cannot detect colistin resistance appropriately. Even commercial susceptibility systems fail in this regard. Keeping in mind the importance of surveillance of colistin-resistant bugs, we present an update on the prevalence, mechanism of resistance, and detection.

Citing Articles

Evaluation of different methods for susceptibility testing of colistin in carbapenem resistant Gram-negative bacilli.

Rout B, Dash S, Sahu K, Behera B, Praharaj I, Otta S Access Microbiol. 2023; 5(10).

PMID: 37970087 PMC: 10634484. DOI: 10.1099/acmi.0.000595.v3.

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