The Role of Platelets in the Regulation of Tumor Growth and Metastasis: the Mechanisms and Targeted Therapy

Overview

Journal MedComm (2020)

Specialty Health Services

Date 2023 Sep 18

PMID 37719444

Authors

Kaili Liao

Xue Zhang

Jie Liu

Feifei Teng

Yingcheng He

Jinting Cheng

Qijun Yang

Wenyige Zhang

Yuxuan Xie

Daixin Guo

Gaoquan Cao

Yanmei Xu

Bo Huang

Xiaozhong Wang

Affiliations

Soon will be listed here.

Abstract

Platelets are a class of pluripotent cells that, in addition to hemostasis and maintaining vascular endothelial integrity, are also involved in tumor growth and distant metastasis. The tumor microenvironment is a complex and comprehensive system composed of tumor cells and their surrounding immune and inflammatory cells, tumor-related fibroblasts, nearby interstitial tissues, microvessels, and various cytokines and chemokines. As an important member of the tumor microenvironment, platelets can promote tumor invasion and metastasis through various mechanisms. Understanding the role of platelets in tumor metastasis is important for diagnosing the risk of metastasis and prolonging survival. In this study, we more fully elucidate the underlying mechanisms by which platelets promote tumor growth and metastasis by modulating processes, such as immune escape, angiogenesis, tumor cell homing, and tumor cell exudation, and further summarize the effects of platelet-tumor cell interactions in the tumor microenvironment and possible tumor treatment strategies based on platelet studies. Our summary will more comprehensively and clearly demonstrate the role of platelets in tumor metastasis, so as to help clinical judgment of the potential risk of metastasis in cancer patients, with a view to improving the prognosis of patients.

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